The University of Tokyo

Riken Corporation

National Institutes for Quantum Science and Technology

Ichio Aoki

Kazunori Kataoka

Nobuhiro Nishiyama

Yutaka Miura

Takuzo Aida

Akihiro Kishimura

Toshiaki Takeuchi

Horacio Cabral

Tsuneo Saga

Daigo Miyajima

Seunghyun Sim

Peng Mi

Daisuke Kokuryo

Provided is a novel nanoparticle, a contrast agent for magnetic resonance imaging containing the same, and a ligand compound used for production of the nanoparticle. The present invention relates to a nanoparticle including: a metal particle containing iron oxide; and a ligand which is bound to a metal atom on a surface of the metal particle and is represented by formula (3): 

Nanoparticle, contrast agent for magnetic resonance imaging containing same, and ligand compound

The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.

Polymer nanoparticle composite and composition for MRI imaging including same

Growing community of inventors

Chiba, Japan

Ichio Aoki