Bayer Corporation

Closure Medical Corporation

Ethicon, Gmbh

Ibraheem T Badejo

Daphne J Rice

Upvan Narang

Daniel L Hedgpeth

Gabriel N Szabo

William S C Nicholson

Lawrence H Mainwaring

Leo B Kriksunov

Julian A Quintero

Keith R D'Alessio

Jerry Y Jonn

Michael J Greene

Andres Rivera

Anthony J Sherbondy

Joe B Barefoot

Margot Campos

Shane A Lacy

John F Britanak

Guenter G Franke

Teresa Marie Warren

Brian McCrum

Wendy Y Su

Jaime Ayarza

Bernard Miles Malofsky

Timothy P Hickey

William M Cotter

Ubonwan A Stewart

Anthony S Voiers

Julian QUintero

Charles E Shannon

Melanie Vander Klok

Niran Nugara

Mary Jo S Rivera

Michelle Knotts

Roy F Thompson, Jr

Robert V Toni

Jeffrey R Hennenkamp

Kenneth W Davis

A reinforcing incision drape for tissue, such as fragile tissue, includes an absorbable surgical mesh having top and bottom major surfaces. The absorbable surgical mesh has a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The stitching zone is less porous and the first and second reinforcing zones are more porous than the stitching zone. A releasable liner covers the top major surface of the absorbable surgical mesh within the stitching zone of the absorbable surgical mesh. A weaker adhesive, such as a pressure sensitive adhesive, covers the bottom major surface of the surgical mesh within the centrally located stitching zone of the absorbable surgical mesh, and a stronger adhesive, such as cyanoacrylite, covers the first and second reinforcing zones of the absorbable surgical mesh.

Reinforcing incision drapes having stitching zones bounded by reinforcing zones for closing incisions formed in fragile tissue

A method of reinforcing subcutaneous fragile tissue includes obtaining an absorbable surgical mesh having top and bottom major surfaces, the absorbable surgical mesh including a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The method includes making an incision in a patient's skin for exposing subcutaneous fragile tissue, using one or more absorbable adhesives for adhering the bottom major surface of the absorbable surgical mesh to the subcutaneous fragile tissue, creating an incision through the stitching zone of the absorbable surgical mesh and into the subcutaneous fragile tissue, performing a surgical procedure through the incision, and passing an absorbable suture through the stitching zone of the absorbable surgical mesh and the fragile tissue for closing the incision.

Systems and methods for closing incisions formed in fragile tissue

An adhesive composition includes one or more polymerizable cyanoacrylate monomers, a polymerization initiator and a polymerization accelerator for the one or more polymerizable cyanoacrylate monomers. A system for treating living tissue includes a first reservoir containing one or more polymerizable cyanoacrylate monomers, a second reservoir in a non-contacting relationship with the first reservoir containing a polymerization initiator and accelerator for the one or more polymerizable cyanoacrylate monomers, and an applicator capable of combining the polymerizable cyanoacrylate monomer and the polymerization initiator and accelerator to form an adhesive composition and then applying the adhesive composition to living tissue. The initiator may be a quaternary ammonium salt, and the accelerator may be a trihydroxy tertiary amine.

Controlled exotherm of cyanoacrylate formulations

A polymerizable adhesive composition comprises at least one &#x3b1;-cyanoacrylate monomer and at least one absorbable viscosity modifying agent. The absorbable viscosity modifying agent has repeated units of the following structure: Ris a methyl group or a hydrogen. Ris a straight, branched or cyclic alkyl group having from 1 to 6 carbon atoms. Ris a straight, branched or cyclic alkyl group having from 1 to 12 carbon atoms, and n is 2 or more.

Viscous &#x3b1;-cyanoacrylate compositions

Liquid coating compositions are provided that comprise siloxane containing polymer, volatile polydimethylsiloxane, and aliphatic hydrocarbon. The liquid coating compositions preferably comprise from 18-55 weight % of volatile polydimethylsiloxane, from 5-55 weight % of aliphatic hydrocarbon, from 1-40 weight % of siloxane containing polymer, and from 0-15 weight % of adjuvant.

Liquid coating compositions

A method of treating or preventing tinea pedis, commonly known as Athlete's Foot, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea pedis, optionally with at least one of an additional anti-fungal agent or a foot care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Adhesive treatment for tinea pedis

A polymerizable monomer adhesive composition includes a 1,1-disubstituted ethylene monomer and at least one slip additive, where the slip additive causes a polymer film formed from the monomer to have a lower coefficient of friction than in an absence of the slip additive. The slip additive can be selected from, inter alia, fluorinated monomers or polymers, fluorinated additives, siloxane-containing monomers or polymers, siloxane-containing additives, fluorinated siloxanes, and long chain fatty acid esters. The slip additive can also form a second phase in a resultant polymer film, where the second phase is soluble in the monomer but is insoluble or substantially insoluble in the polymer.

Adhesive compositions with reduced coefficient of friction

An adhesive composition includes a polymerizable adhesive monomer and at least one antioxidant stabilizer, and/or a container for storing said monomer composition that includes an antioxidant stabilizer. The antioxidant stabilizer provides superior stabilization and shelf-life of the composition and/or the container, and may enhance wound healing properties of the monomer composition.

Antioxidant enriched adhesive compositions and storage containers therefor

A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.

Applicator for dispensable liquids

An adhesive composition that contains a preservative is particularly useful as a medical adhesive and can include alkyl cyanoacrylate monomers. The preservative is preferably soluble in the monomer. The composition may optionally be sterilized by placing a mixture of a polymerizable adhesive monomer and a preservative in a container, sealing the container, and sterilizing the mixture and the container.

Cyanoacrylate solutions containing preservatives

Preparation of quinacridone pigment compositions

A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.

Method of applying an adhesive composition over a bioactive polymerization initiator or accelerator

Continuous processes for forming cyanoacrylate from polycyanoacrylate include stripping a solvent from a reaction mass; cracking a polymer in the reaction mass to form a cracked cyanoacrylate monomer and residue substances; and distilling the cracked cyanoacrylate monomer to produce a cyanoacrylate monomer product. These steps can be performed in short-path, wiped-film evaporators. Polycyanoacrylate used in the processes can be formed using cyanoacetate produced by processes for continuously producing cyanoacetate by forming a higher homologue cyanoacetate from a lower homologue cyanoacetate. The cyanoacetate can be formed in short-path, wiped-film evaporators.

Continuous processes and apparatus for forming cyanoacetate and cyanoacrylate

An &agr;-cyanoacrylate may be formed by first condensing a cyanoacetate with paraformaldehyde or formaldehyde; reacting the polymer formed with an alcohol to transesterify the polymer; and depolymerizing the polymer to form &agr;-cyanoacrylate monomers.

Transesterification method for making cyanoacrylates

This invention relates to pigment derivatives having the formula ##STR1## wherein Q represents an organic pigment moiety;

Pigment derivatives for waterborne coatings

Growing community of inventors

Raleigh, NC, United States of America

Ibraheem T Badejo