Eszakmagyarorszagi Vegyimuvek

Richter Gedeon Nyrt.

Cytrx Corporation

Ibolya Horváth

Gábor Balogh

Zsolt Török

Laszlo Vigh

László Vígh

Tibor Farkas

László Ürögdi

Zsolt Dombay

Jozsef Nagy

Ede Márványos

Istvan Toth

Ferenc Fülöp

Péter Literáti Nagy

Mária Kürthy

György Dormán

Botond Penke

László Korányi

Katalin Bíró

Sándor Bernáth

Beatrix Farkas

Attila Glatz

Andrea Jednákovits

Mihály Barabás

Erzsébet Hegedüs

Éva Udvardy

Dénes Medzihradszky

Bea Mézes

Eszter Kovács

Ákos Hunya

László Jaszlits

Erzsebet Grega Nee Toth

Gyula Tarpai

Csaba Pavliscsak

Laszlo I Horvath

Jenö Szilbereky

László Vigh

Emilia Nagy Nee Gera

Ferenc Foglein

Aniko Nagy Nee Vanicsek

Annamaria Meszaros

Ernö Duda

Jenó Szilbereky

Ernó Duda

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein Ris optionally substituted Caryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; Rand Rare independently hydrogen or Calkyl group; Rand Rare independently hydrogen, Calkyl group optionally substituted with amino, mono- or di(Calkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with Calkyl group or Calkoxy group; Ris Calkyl, Ccycloalkyl, CcycloalkylCalkyl or arylCalkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins. 

1,4-dihydropyridine derivatives with HSP modulating activity

1,4-dihydropyridine derivatives with Hsp modulating activity

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof

Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof

Disclosed is a process for improving the efficiency of in vitro propagation and tissue cultivating by tissue culture of cultivated of plants which comprises treating the plants during micropropagation and/or subsequent planting with an aqueous solution of one or a mixture of substituted amides or one or a mixture of substituted diamides.

Plant tissue cultivation process

The invention relates to a plant growth regulating composition which contains as active agent a compound of general formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can be identical or different and can stand for hydrogen, a C.sub.1-4 straight or branched alkyl group, cyclohexyl, phenyl, chlorophenyl, alkylphenyl, benzyl or alkylbenzyl group, or R.sub.1 and R.sub.2 can together with the N atoms form a heterocyclic ring. The growing of plants can be stimulated and the green weight can be increased to a significant degree by the treatment carried out with the composition of the invention.

Plant growth regulating method

The invention relates to new compositions for increasing the cold resistance of cultivated plants. These compositions contain as active ingredient at least one compound of the general formula (I), ##STR1## wherein n is an integer of 2 to 5 and R.sub.1, R.sub.2 and R.sub.3 each stand for hydrogen or C.sub.1-5 alkyl, or an acid addition salt thereof in an amount of 0.01 to 70% by weight, together with a conventional diluent and/or additive. The plants treated with the compositions according to the invention are more resistant to cold and frost.

Compositions for increasing the cold resistance of cultivated plants and

Growing community of inventors

Szeged, Hungary

Ibolya Horváth