Novo Nordisk A/s

Pulse Mems Aps.

Mpm-holding Aps

Sonion Lyngby A/s

Ib Johannsen

Matthias Mullenborn

Roice Michael

Morten P Meldal

Dorothee Ambrosius

Niels Bent Larsen

Soren Flygenring Christensen

Jens Hog Truelsen

Pirmin Hermann Otto Rombach

Patrik Gavelin

Alexander Jacobi

Monica Ramos Gallego

Franz Nothelfer

The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilized particles. The spatial immobilization of the particles confers on each beaded polymer matrix a 'fingerprint' which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.

Spatially encoded polymer matrix

The present application discloses a method of modifying a macromolecule, the method comprising the steps of (i) providing the macromolecule; (ii) providing a compound of the general formula (I): wherein N is a primary amino group protected with the protecting group P, wherein the protecting group involves both free valences of the primary amino group; m is an integer of 1-12 and n is an integer of 1-2000; Rand Rare independently selected from the group consisting of hydrogen and C-alkyl; and X is a reactive group; and (iii) allowing the compound of the general formula (I) to react with the macromolecule so as to form grafts on the macromolecule. Compounds of the general formula (i) and a method for the preparation thereof are also disclosed.

Method of modifying a macromolecular system

A method of providing at least part of a diaphragm and at least a part of a back-plate of a condenser microphone with a hydrophobic layer so as to avoid stiction between said diaphragm and said back-plate. The layer is deposited via a number small of openings in the back-plate, the diaphragm and/or between the diaphragm and the back-plate. Provides a homogeneous and structured hydrophobic layer, even to small internal cavities of the microstructure. The layer may be deposited by a liquid phase or a vapor phase deposition method. The method may be applied naturally in continuation of the normal manufacturing process. Further, a MEMS condenser microphone is provided having such a hydrophobic layer. The static distance between the diaphragm and the back-plate of the microphone is smaller than 10 &#x3bc;m.

Method of providing a hydrophobic layer and condenser microphone having such a layer

Method of providing a hydrophobic layer and a condenser microphone having such a layer

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Vaerlose, Denmark

Ib Johannsen