Phaeton Research Limited

Zysis Limited

Ian Wilding

Peter John Houzego

Peter Neil Morgan

Duncan James Westland

Peter Hanson Hirst

Russell Pendleton

An orally deliverable pharmaceutical composition provides controlled release of aripiprazole. The composition includes a therapeutically effective amount of aripiprazole and at least one pharmaceutically acceptable excipient. The compositions of the invention may exhibit one or more of the release profiles defined in the specification.

Pharmaceutical compositions of aripiprazole

An ingestible device for delivering a substance to a chosen location in the GI tract of a mammal includes a receiver of electromagnetic radiation for powering an openable part of the device to an opened position for dispensing of the substance. The receiver includes a coiled wire that couples the energy field, the wire having an air or ferrite core. In a further embodiment the invention includes an apparatus for generating the electromagnetic radiation, the apparatus including one or more pairs of field coils supported in a housing. The device optionally includes a latch defined by a heating resistor and a fusible restraint. The device may also include a flexible member that may serve one or both the functions of activating a transmitter circuit to indicate dispensing of the substance; and restraining of a piston used for expelling the substance.

Ingestible device

The field of the invention is site-specific drug delivery capsules (SSDC's). The disclosure relates to a closure member () for a substance reservoir () of an SSDC (). The SSDC () includes a retainer that provides a non-linear force resisting opening of the closure member (). The non-linear force ensures that the closure member () unseals the reservoir () only when an opening force exceeds a maximal value of the resisting force, thereby preventing premature or accidental emptying of the reservoir (). The preferred means of providing the resistive force is a rolling, elastomeric o-ring () that additionally seals the closure member () into an aperture ().

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Nottingham, United Kingdom

Ian Wilding