Kudos Pharmaceuticals Limited

Maybridge Limited

Kudo Pharmaceuticals Limited

Ian Timothy Williams Matthews

Keith Allan Menear

Niall Morrison Barr Martin

Xiao-Ling Fan Cockcroft

Stephen Philip Jackson

Alan Ashworth

Frank Kerrigan

Graeme Cameron Smith

Vincent Junior M Loh

Graeme Cameron Murray Smith

Roger John Griffin

Laurent Jean Martin Rigoreau

Marc Geoffrey Hummersone

Mark O'Connor

Alan Yin Kai Lau

Marc Geoffery Hummersone

Stephen P Kudos Pharmaceuticals Ltd Jackson

Niall M B Kudos Pharmaceuticals Ltd Martin

Graeme C M Kudos Pharmaceuticals Ltd Smith

Alan Y K Kudos Pharmaceuticals Ltd Lau

Mark J Kudos Pharmaceuticals Ltd O'CONNOR

Xiao-Ling Fan Chemovation Ltd Cockcroft

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X&#x2550;NRthen n is 1 or 2 and if X&#x2550;CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and Ris selected from H and halo.

Phthalazinone derivatives

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X&#x2550;NRthen n is 1 or 2 and if X&#x2550;CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; andRis selected from H and halo.

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X&#x2550;NRthen n is 1 or 2 and if X&#x2550;CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X=NRthen n is 1 or 2 and if X=CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and Ris selected from H and halo.

A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: Rand Rtogether form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and Ris selected from hydrogen, an optionally substituted Calkyl group, an optionally substituted Cheterocyclyl group, an optionally substituted Caryl group, an acyl group, an ester group and an amido group, and its use as a pharmaceutical.

ATM inhibitors

The application concerns a compound of formula I:wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the Rgroup;

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Horsham, United Kingdom

Ian Timothy Williams Matthews