Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Ian Thomas Huscroft

Janusz Jozef Kulagowski

Piotr Antoni Raubo

Christopher John Swain

Neil Roy Curtis

David A Claremon

Leslie Joseph Street

Eileen Mary Seward

Richard Thomas Lewis

Wesley Peter Blackaby

Wayne J Thompson

Jason Matthew Elliott

Francine Sternfeld

Clare London

Duncan Edward Shaw

Peter M Munson

Graeme Irvine Stevenson

Sylvie Bourrain

Peter Alan Hunt

Linda Elizabeth Keown

Richard Alexander Jelley

Elizabeth Mary Naylor

Joanne Thomson

Christopher George Thomson

Willie Whitter

Olivier Dirat

Brain J Williams

A compound of the formula (I): wherein R, R, R, R, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia. 

Inhibitors of GLYT1 transporters

The present invention relates to compounds of formula (Ia) wherein A, B, n, m, R, R, R, R, R, R, R, R, R, Rand Rare defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Tetrahydropyran compounds as tachykinin antagonists

The present invention relates to sulfone derivatives of formula (I):Ar&#x2014;SO&#x2014;CRR-L-N(R)Iwherein Ar, L, R, Rand Rare as defined herein, and pharmaceutically acceptable salts and N-oxides thereof, useful in the treatment of a condition which is susceptible to treatment by modulation of 5-HTreceptor activity, such as depression or a sleep disorder.

Sulfone derivatives as 5-HT7 receptor ligands

Azabicyclic ether derivatives and their use as therapeutic agents

Azabicyclic spiroether derivatives and their use as therapeutic agents

Novel piperidinyl compounds substituted in the 1- and 4-positions are effective as NMDA NR2B antagonists useful for relieving pain.

1,4 substituted piperidinyl NMDA/NR2B antagonists

Spiro-piperidine derivatives and their use as therapeutic agents

Alcohols and ethers with aromatic substituents as tachykinin-antagonists

Growing community of inventors

Bishops Stortford, United Kingdom

Ian Thomas Huscroft