Bristol-myers Squibb Compnay

Ian Scott Young

Jay Patrick Powers

Hunter Paul Shunatona

Maureen Kay Reilly

Mikhail Zibinsky

Maksim Osipov

Hilary Plake Beck

James Ross Walker

Sanjeev Gangwar

Benjamin Cohen

Shoshana L Posy

Prasanna Sivaprakasam

Petinka I Vlahova

Yam B Poudel

Jennifer Leigh Nelson

Gregory L Beutner

Michael S Bultman

Sergei Kolotuchin

Yu Fan

Francisco Gonzalez-Bobes

Kenneth Joseph Fraunhoffer

Adam Joseph Freitag

Tamar Rosenbaum

Albert J Delmonte

Prantik Maity

Sha Lou

The present disclosure relates to amorphous and crystalline forms of (R)—N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Amorphous and crystalline forms of IDO inhibitors

The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation

The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.

Antibody-drug conjugate with a tubulysin analog warhead having a stabilized acetate group in the TUV subunit

Compounds having a structure according to formula (I), (II), or (III) where R, R, R, RX, X, and Xare as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor

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Redwood City, CA, United States of America

Ian Scott Young