Children's Medical Center Corporation

Ian S Ramsey

Jayhong A Chong

Magdalene M Moran

David Clapham

Nucleic acid and protein sequences relating to a proton channel (Hv1) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the Hv1 gene and protein are disclosed. Also provided are methods of identifying modulators of Hv1 activity, methods of geno typing subjects with respect to Hv1, and methods of diagnosing and treating Hv1-mediated disorders.

Methods of using voltage-gated Hv1 proton channels to detect changes in intracellular pH

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.

Sperm-specific cation channel, CATSPER3, and uses therefor

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.

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Boston, MA, United States of America

Ian S Ramsey