Elizabeth Arden Company, Division of Conopco, Inc.

Unilever Home and Personal Care Usa, Division of Conopco, Inc.

Chesebrough-pond's USA Co., Division of Conopco, Inc.

Synergy Biosystems Ltd

Conopco, Inc.

Unilever Patent Holdings B.v.

Unilever Home & Personal Care Usa, a Division of Conopco, Inc.

Elizabeth Arden Co.

Ian Richard Scott

Stewart Paton Granger

Anthony V Rawlings

Anthony Vincent Rawlings

Susanne Teklits Iobst

Peter Critchley

Allan Robert Burger

Clive Roderick Harding

Lisa Licameli

Robert Mark Donovan

Susan E Kirsch

Prem Chandar

Julia Sarah Rogers

John Anthony Bosley

Desmond B Hagan

Christopher Rawlins

Anthony P Taylor

Kevin Ronald Franklin

Victor DeFlorio

Sreekumar Pillai

Charles Craig Nunn

Ronni Lynn Weinkauf

David Joseph Pocalyko

Kelly Hua Zhang

Marieann Barratt

Stuart William Carr

Koichi Iwata

Duncan J Crawford

Simon M Jackson

Endah Sulistyowati

Dwiwahyu Haryo Suryo

Caroline Marian Lee

Jonathan David Hague

Richard John Kosturko

David T Parrot

David T Parrott

Jeffrey J Pasternak

A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of at combination of retinoid boosters.

Method for treating skin with retinoids and retinoid boosters

A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters.

Method for treating skin with booster compositions

A method of producing a retinyl ester compound comprising subjecting a composition comprising retinyl or a retinyl ester and a fat or oil of animal or vegetable origins to enzyme catalysed trans-esterification in solvent free conditions to produce a retinyl ester.

Method of producing retinyl esters

Skin conditioning compositions containing compounds for mimicking the effect on skin of retinoic acid

Methods are described using a particular type of assay system, the Multi-Pathway High Throughput Assay, in conjunction with a novel experimental strategy, whereby repeated cycles of experiments result in the identification of the most effective synergistic combinations of potential active agents from a library of materials. The novel experimental strategy not only requires far fewer total experiments than would be required using conventional discovery strategies but also maximizes the probability of finding highly synergistic combinations through the principle of multiple-pathway intervention.

Methods to identify biologically active agents and synergistic combinations

The method employs a piece of skin of area greater than 1 cmcultured under conditions that maintain its viability and substantially normal structure for sufficient time for topically applied test material to potentially exert an effect. The skin includes the majority of the epidermal layer plus an appropriate amount of supporting dermis. The surface of the skin is partitioned by a surface barrier film into a pattern of isolated regions to which different test materials can be subsequently topically applied in such a way that they do not significantly migrate around the edges of the skin into the culture medium. The effect of the topically applied material on the skin is determined using an appropriate method. In a variant of the method, the temperature of the culture system is maintained at or below about 30&#xb0; C. to improve the skins viability and maintain a substantially normal structure. The invention encompasses effective topically applied materials identified using the methods described herein.

Method to measure the effect of topically applied agents using skin maintained in organ culture

A stable skin care composition containing about 0.0001% to about 50% of at least one retinoid booster, about 0.001% to about 10% of a retinoid; and a cosmetically acceptable vehicle, wherein the stable skin care composition is contained in a package so that the composition is out of contact with oxygen.

Stable skin care compositions containing a retinoid and a retinoid booster system

A cosmetic product is provided packaged in a dispenser with separate first and second storage areas. The first of the areas contains a first cosmetic composition containing a first dermal active agent, preferably selected from keratolytic skin agents. Particularly preferred are alpha- and beta-hydroxy carboxylic acids as first dermal active placed in a composition having a pH from about 1 to about 5.5. The second area contains a second cosmetic composition with a second dermal agent incompatible with the first composition. Particularly preferred second dermal agents are retinoids, vitamins, enzymes and anti-oxidants. Most preferred is retinol. The dispenser allows transfer of the first and second compositions through an exit nozzle in a respective dispensing weight ratio of from about 30:1 to about 2:1.

Dual composition cosmetic product with a concentration sensitive and an incompatible active respectively placed within first and second compositions

A stable skin care product containing a first composition comprising about 0.001% to about 10% of a retinoid; a second composition comprising about 0.001% to about 10% of a phytoestrogen; a first compartment for storing the first composition; and a second compartment for storing the second composition, the first and second compartments being joined together.

Skin care product containing retinoids and phytoestrogens in a dual compartment package

Cosmetic skin care compositions containing a high performing retinyl ester which is an ester of retinol with C , unsaturated, non-essential, cis-6 and/or cis-12 fatty acid. The ester is preferably selected from the group consisting of gamma-retinyl linolenate, retinyl petroselinate, and retinyl cis-12-octadecenoate.

Cosmetic skin conditioning compositions containing high performing retinyl esters

N-substituted fatty acid amides which sufficiently inhibit LRAT or ARAT catalyzed esterification of retinol into inactive retinyl esters, have the same effect on keratinocytes as retinoic acid. Thus, effects of the retinol or retinyl esters in combination with N-substituted fatty acid amides are analogous to treatment with retinoic acid.

Skin care compositions containing an n-substituted fatty acid amide and

Fatty acid amides, but not free fatty acids or fatty acid esters, in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with fatty acid amides were analogous to treatment with retinoic acid.

Skin care compositions containing fatty acid amides and retinol or

Certain cyclic aliphatic unsaturated compounds which sufficiently inhibit LRAT or ARAT catalyzed esterification of retinol into inactive retinyl esters, have the same effect on keratinocytes as retinoic acid. Thus, effects of the retinol or retinyl esters in combination with these cyclic compounds are analogous to treatment with retinoic acid.

Skin care compositions containing certain cyclic aliphatic unsaturated

Geranyl geraniol inhibits esterification of retinol into inactive retinyl esters. Thus, effects of the retinol or retinyl esters in combination with geranyl geraniol are analogous to treatment with retinoic acid.

Skin care compositions containing geranyl geraniol and retinol or

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Allendale, NJ, United States of America

Ian Richard Scott