University of Cincinnati

Eccrine Systems, Inc.

Ian Papautsky

Jason C Heikenfeld

Xiao Wang

Daniel P Rose

Wenjing Kang

Michael Ratterman

Joshua Andrew Hagen

Jian Zhou

Morley O Stone

Rajesh R Naik

Li Shen

Ali Asgar S Bhagat

Linlin Hou

Nancy Kelley-Loughnane

John Busbee

Morley Stone

Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.

Sweat simulation, collecting and sensing systems

A method of separating a plurality of particles () from a portion of fluid, comprising directing the plurality of particles () into a microchannel (). A first portion () of particles () is focused into an equilibrium position in the microchannel (). The focused first portion () is directed into a first outlet () aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (). A microfluidic device () for separating a plurality of particles () from a portion of fluid, comprising a microchannel () having a first aspect ratio and a length L, thereby focusing the particles () directed therein into an equilibrium position in the microchannel, wherein at least a first portion () of the particles () focuses at distance X from a beginning of the microchannel (). A first outlet () disposed after distance X and aligned with the equilibrium position to receive at least the first portion () of the particles () after the first portion () focuses into an equilibrium position in the microchannel (). At least a second outlet () for receiving a second portion of the particles () before the second portion focuses into an equilibrium position.

Microfluidic methods for passive separation of cells and particles

The invention addresses confounding difficulties involving continuous sweat analyte measurement. Specifically, the present invention provides: at least one component capable of monitoring whether a sweat sensing device is in sufficient contact with a wearer's skin to allow proper device operation; at least one component capable of monitoring whether the device is operating on a wearer's skin; at least one means of determining whether the device wearer is a target individual within a probability range; at least one component capable of generating and communicating alert messages to the device user(s) related to: wearer safety, wearer physiological condition, compliance with a requirement to wear a device, device operation; compliance with a behavior requirement, or other purposes that may be derived from sweat sensor data; and the ability to utilize aggregated sweat sensor data that may be correlated with information external to the device to enhance the predictive capabilities of the device.

Sweat sensing device communication security and compliance

Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in the image, converting the intensity data for at least one of the red channel, the green channel, or the blue channel to a first data point, recalling a predetermined standardized curve, comparing the first data point with the standardized curve, and identifying the value for the assay parameter from the standardized curve.

Method and system for analyzing a colorimetric assay

A spiral microchannel particle separator includes an inlet for receiving a solution containing particles, at least two outlets, and a microchannel arranged in a plurality of loops. Particles within a solution flowing through the spiral microchannel experience a lift force Fand a Dean drag force F. The spiral radius of curvature R and the hydraulic diameter Dof the spiral microchannel are such that for a flow rate U of the solution, the lift force Fand a Dean drag force Fare approximately equal and act in opposite directions for particles of a first size. The particles of the first size are focused in a single stream located at an equilibrium position near an inner wall of the microchannel. In another embodiment, a straight microchannel particle separator separates particles by modulating shear rates via high aspect ratios that focuses particles of a first size along two first walls.

Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems

Growing community of inventors

Mason, OH, United States of America

Ian Papautsky