Rhone Poulenc Rorer

May & Baker, Ltd.

Aventis Pharma Limited

Ian Michael McFarlane

Garry Fenton

Andrew David Morley

Malcolm Norman Palfreyman

Andrew James Ratcliffe

Brian William Sharp

Sukanthini Thurairatnam

Michael John Ashton

Nigel Vicker

David Charles Cook

Susan Jacqueline Hills

Bernard Yvon Vacher

Neil Victor Harris

Christopher Smith

Michael J Ashton

David J Lythgoe

David Riddell

Keith A Stuttle

Donald I Dron

Andrew W Bridge

Christopher G Newton

Robert K Chambers

Bernard Yvon Jack Vacher

Malcolm P Toft

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-

Compounds containing phenyl linked to aryl or heteroaryl by an

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

Growing community of inventors

Dagenham, United Kingdom

Ian Michael McFarlane