Colorado State University Research Foundation

Globeimmune, Inc.

Ian M Orme

Thomas H King

Zhimin Guo

John T Belisle

Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.

Compositions and methods for the treatment or prevention of tuberculosis

Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective immunity has waned comprise one or more purified immunogenic proteins fromfrom a group of 30 proteins that stimulate T cell immunity and interferon-&#x3b3; secretion. A preferred protein is Ag85A, the secreted product (SEQ ID NO:31) of the Rv3084c gene. Also disclosed are methods for boosting immunity in such BCG-vaccinated subjects comprising administering an effective amount of the above vaccine composition.

Growing community of inventors

Fort Collins, CO, United States of America

Ian M Orme