Eastman-kodak Company

Ge Healthcare As

Ge Healthcare Limited

Reckitt & Colman Inc.

Nanosystems L.l.c.

Ian M Newington

Alan R Pitt

Trevor J Wear

Harry John Wadsworth

Duncan George Wynn

David Erdtmann

Andrew M Howe

Danuta Gibson

Dennis O'Shea

John H Hone

Charles Chester Anderson

Mary Christine Brick

Kristine B Lawrence

Janglin Chen

Gregory L McIntire

Oskar Axelsson

John W Boettcher

Gary Norman Barber

Julie Baker

Mark A Harris

Karen Ann McCue

Julian Grigg

Matthias Eberhard Glaser

Judith L Fleissig

Christopher John Winscom

John M Higgins

Harjit Singh Bhambra

Sui-Ming Wong

Imtiaz Ahmed Khan

Steven Michael Fairway

Peter Hewitson

Malcolm D Purbrick

Joanna Marie Passmore

Clare Louise Jones

Dawn J Jenkins

Kevin J Parr

Amanda Ewan

Veronique Morisson-Iveson

Catherine B Briggs

Elaine M Liversidge

Malcom D Purbrick

Jack M Shaw

Patricia I Bowman

Katie E Adams

Gareth Edwin Smith

Phillip J Coldrick

Marie C Bunce

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to automated methods for the preparation and purification ofF-labelled tau imaging radiotracers. Also provided are interchangeable cassettes useful in the methods, and the use of automated synthesizers and cassettes in the methods.

Radiolabelling method

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R&#x2014;Y&#x2014;X&#x2014;Z&#x2014;R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

Contrast agents

The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).

Paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (MRI)

A thermally-responsive dispersant for an aqueous dispersion of positively- or negatively-charged or chargeable solid or liquid particulates, comprises a compound having an anchoring moiety linked to a thermally-responsive polymeric stabilizing moiety, other than a polyalkylene oxide, the polymeric moiety having a lower affinity for the surface than the anchoring group below the thermal transition temperature, the particulates being positively-charged or chargeable when the anchoring moiety contains an acid and/or hydroxy group and has a net acidity or neutrality and the particulates being negatively-charged or chargeable when the anchoring moiety has a basic group and has a net basicity, wherein the dispersion exhibits a change in sign from negative to positive and an increase in magnitude of a rheological property (viscosity at low shear and/or complex modulus at low amplitude oscillatory shear), on increasing the temperature from below to above the thermal transition temperature.

Thermally-responsive dispersants for media formulations

The invention provides a dispersant for an aqueous dispersion of negatively charged or chargeable solid particulates which comprises a compound having an anchoring moiety linked to a polymeric hydrophilic moiety, the anchoring moiety containing at least one basic group and having an overall basicity and the polymeric moiety having a lower affinity for the particulate surface than the anchoring moiety. The invention also provides a coating composition containing the dispersant, an inkjet recording element containing the dispersant and methods of coating or reducing viscosity using the dispersant.

Coating composition containing a dispersant

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.

Chelating agents

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

A substantially transparent conductive layer is provided on a support, the layer comprising a conductive ionic liquid and a conductive metal network distributed therein.

Transparent conductive system

The present invention provides a planographic printing element suitable to receive and bond with a subsequently applied hydrophilic layer comprises a substrate layer, such as polyester film or paper, having coated thereon an adhesion layer, said adhesion layer comprising a polymer having a glass transition temperature of less than 15C and containing functional groups such as hydroxyl, epoxy or glycidyl groups capable of reacting with the hydrophilic layer. The polymer may be a terpolymer of a hydroxyalkyl methacrylate, an alkyl acrylate and an aminoalkyl methacrylate. The polymer may be mixed with gelatin and the mixture applied to the substrate as a coating. The hydrophilic layer, which may comprise metal oxide particles, such as aluminium oxide and/or titanium dioxide particles in a sodium silicate binder, is subsequently applied as a coating to the adhesion layer.

Adhesion promoting polymeric materials and planographic printing elements containing them

A coating fluid for forming a coating on a support for use in inkjet printing comprises a liquid medium having dispersed therein (a) an inorganic oxide selected from aluminium oxide and silica, (b) a binder polymer, and (c) a polymeric crosslinking agent containing functional groups for reaction with the inorganic oxide. The components (a), (b) and (c) are preferably dispersed in an aqueous liquid and the relative amounts of inorganic oxide to polymeric crosslinking agent are from 500:1 to 15:1 preferably 250:1 to 20:1, the relative amounts of inorganic oxide to binder polymer are from 50:1 to 2:1 preferably 20:1 to 4:1 and the relative amounts of binder polymer to polymeric crosslinking agent are from 40:1 to 2:1 preferably from 20:1 to 3:1 the amounts being by weight on a dry basis.

Coating fluid for the preparation of a recording medium for use in inkjet printing

Solid particle dispersions and their use in the preparation of laser thermal media

A method for the preparation of a lithographic printing plate comprises forming an oleophilic image on the surface of a hydrophilic support by depositing, preferably by ink-jetting, the desired image on the surface using an aqueous emulsion of an organic film-forming polymer which has been prepared by emulsion polymerization, whereby the polymer adheres to the surface of the printing plate forming an oleophilic film. The polymer preferably has functional groups such as sulphonate that bind the polymer to the hydrophilic surface. Preferably the polymer has a glass transition temperature of not greater than about 105&deg; C. and where the glass transition temperature is above 50&deg; C. the polymer, after deposition on the plate, is preferably subjected to a heat treatment to assist in film formation.

Lithographic printing plates and method for their preparation

An ink jet ink composition comprising from about 0.5% to about 30% by weight of a pigment, a carrier and a dispersant, the dispersant comprising an anionic derivative of an ethoxylated alkylphenol-formaldehyde resin, the ratio of dispersant:pigment being from about 0.1:1 to about 5:1.

Ink jet ink

Ink jet printing method

Growing community of inventors

Hazlemere, United Kingdom

Ian M Newington