Merck Sharp + Dohme Corp.

Merck Sharpe & Dohme Corp.

Ian M Mawer

Janusz Jozef Kulagowski

Paul D Leeson

Michael Rowley

Paul David Leeson

Howard Barff Broughton

Raymond Baker

Neil Roy Curtis

Mark Peter Ridgill

A class of substituted 1,2,3,6-tetrahydropyridine derivatives are disclosed that are ligands for dopamine receptor subtypes within the body. These compounds are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia or depression.

Tetrahydropyridine derivatives as dopamine receptor subtype ligands

Benzofuran derivatives as D.sub.4 receptor antagonists

Indole derivatives as dopamine D.sub.4 antagonists

Quinolone derivatives as dopamine D.sub.4 ligands

A class of 4-hydroxy-2-(1H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

Hydroxyquinolone derivatives

A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

Tetramic acid derivatives

This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.

Hydroxyquinolone derivatives compounds which have pharmaceutical utility

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Bishops Stortford, United Kingdom

Ian M Mawer