Gi Dynamics, Inc.

C. R. Bard, Inc.

Endius, Inc.

Ian K Parker

Andy H Levine

David A Melanson

Barry Maxwell

Alan E Shluzas

Augustus Felix

Ronald B Lamport

John Conidi

Peter J Shank

James H Loper

Devang Vijay Shah

Scott Schorer

Donald Anthony Coelho, Jr

Ryan Hanlon

John Panek

Nicholas Williams

Peter Maughan Crapo

Nicholas Cote

Sean K Holmes

Stephen T Cassidy

The present invention provides delivery systems for positioning a gastrointestinal implant in a patient, for example, for treatment of a metabolic disease. Also provided are methods for assembling the delivery systems, methods of positioning a gastrointestinal implant, and methods of treatment of metabolic diseases, such as type 2 diabetes, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), obesity, and related comorbidities thereof.

Gastrointestinal implant delivery systems and methods

Surgical devices for use with robotic surgical systems and their methods of use are described. In some embodiments, the surgical device may include an actuator that interfaces with an end effector of an arm of a robotic surgical system. An output from the end effector may actuate the actuator to perform an operation of the surgical device. In some embodiments, the surgical device may include a retainer that retains at least a portion of the surgical device on a distal portion of the arm of the robotic surgical system during actuation. In other embodiments, the surgical device may include a portion that is engaged by a second robotic surgical arm to hold at least a portion of the surgical device stationary relative to the robotic surgical arm engaged with the actuator of the surgical device.

Surgical device for use with robotic surgical systems

An implant () includes a protrusion () with an open or rounded loop () (or open head) connected to a collapsible anchor. The protrusion may include a straight length of wire () or a helical length wire, with one or more wire loops () at the end of the length forming the loop. Upon deployment within the gastrointestinal tract, the protrusion expands from a collapsed state, alongside the anchor, to a relaxed state, in which the protrusion extends outward from the anchor. As the protrusion expands to its relaxed state, it pushes the loop into the wall of the duodenum, causing the loop to penetrate the duodenal wall. A pocket of scar tissue forms about the head and possibly through an opening in the head, securing the anchor within the duodenum. The implant may also include a thin-walled sleeve that is coupled to the anchor and extended from the anchor into the intestine.

Anchors with open heads

The invention relates to improved means for preventing eversion and subsequent obstruction of thin-walled, floppy gastrointestinal liners implanted in the digestive tract of an animal. The implantable devices include an anchor adapted for attachment within a natural body lumen and a thin-walled, floppy sleeve open at both ends and defining a lumen therebetween. A substantial length of the sleeve has material characteristics that result in the sleeve being prone to eversion in the presence of retrograde pressures. Exemplary eversion-resistant features provide an increased stiffness and/or an increased friction coefficient between the anchor and the proximal end of the sleeve to resist eversion. In some embodiments, the eversion-resistant feature includes an anti-buckling element, such as a wire coupled along the substantial length of the sleeve.

Eversion resistant sleeves

A surgical instrument ( ) includes a handle ( ) and a member ( ) for acting on tissue of a patient. A flexible stem ( ) extends between the member ( ) and the handle ( ). The flexible stem ( ) includes a tubular member ( ) having a longitudinal axis ( ) and radially inner and outer cylindrical surfaces ( and ) extending generally parallel to each other. The tubular member ( ) has wedge-shaped slots ( and ) extending through the inner and outer cylindrical surfaces ( and ). Each of the wedge-shaped slots ( and ) is defined by first and second ring portions ( and ) extending at an angle to each other and transverse to the longitudinal axis ( ). An actuator mechanism ( ) connected with the handle ( ) bends the flexible stem ( ).

Surgical instrument

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Bristol, RI, United States of America

Ian K Parker