Ecosynthetix Inc.

Greenmark Biomedical Inc.

Lions Adhesives, Inc.

Ian J McLennan

Steven Bloembergen

Ramani Narayan

Juewen Liu

Nathan Jones

Abdel Elsayed

Do I Lee

David H Fishman

Areet Krsna Ganesh Shermon

Ryan Wagner

Aareet Krsna Ganesh Shermon

Scott E Cassar

Abdel Rahman Elsayed

A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.

Aptamer bioconjugate drug delivery device

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

The present invention provides the novel and nonobvious discovery that sugar macromers can be effectively used to provide a new generation of renewable comonomers for bio-synthetic hybrid paper binder systems having a controlled hydrophilic-hydrophobic balance for improved water retention and film forming properties, on machine runnability, offset printability, biodegradability, enhanced recyclability, and other performance attributes.

Use of biobased sugar monomers in vinyl copolymers as latex binders and compositions based thereon

A method of preparing a resin-fortified polymer emulsion is disclosed. In one embodiment, the method comprises polymerizing at least one monomer in the presence of a surfactant, an initiator, a resin and sugar-based vinyl monomer under emulsion polymerization reaction conditions effective for initiating polymerization, wherein an emulsion polymerization product is formed that comprises a sugar-based vinyl monomer. A composition comprising resin-fortified emulsion polymer comprising a sugar-based vinyl monomer, a resin and at least one emulsion polymerizable monomer is also disclosed. An ink comprising a pigment and a resin-fortified polymer emulsion comprising a sugar-based vinyl monomer, a resin and at least one emulsion polymerizable monomer is also disclosed.

Resin-fortified sugar-based vinyl emulsion copolymers and methods of preparing the same

Copolymers prepared from novel alkyl polyglycoside maleic acid esters and vinyl monomers are biodegradable and repulpable and are useful in adhesives, coatings, sizing agents, toners, retention aids and related polymer resins in paper and paperboard applications, in wood gluing, packaging and other applications.

Environmentally friendly sugar-based vinyl monomers useful in repulpable adhesives and other applications

Sugar based vinyl monomers and copolymers useful in repulpable adhesives

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Burlington, Canada

Ian J McLennan