The Lions Eye Institute of Western Australia, Inc.

The Lions Eye Institute Limited

Avalanche Australia Pty Ltd.

Ian J Constable

Traian V Chirila

Kanagasingam Yogesan

Gabriel Suplewski

Geoffrey J Crawford

Thomas W Chalberg, Jr

Albert V Russo

Chooi-May Lai

Celia R Hicks

P Elizabeth Rakoczy

Matthew David Spark

Dao-Yi Yu

Jean-Pierre Guillon

Thomas W Chalberg

Janet Fitton

Anthony Clayton

Stephen John Cringle

Richard L Cooper

Elizabeth P Rakoczy

The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject.

Treatment of ocular neovascularization using anti-VEGF proteins

An ophthalmic camera () comprising a camera () having a lens () aligned with a second lens () and at least one illumination means (). The illumination means () is capable of movement relative to the camera lens () so that the beam of light emitted by the illumination means () is able to be focused by the second lens () through the pupil onto the fundus. In another embodiment, the ophthalmic camera comprises a camera (), an illumination means () and a beamsplitter (). The camera () and the beamsplitter () from an alignment axis X and the illumination means () together with the beam splitter () form an illumination axis Y perpendicular to the alignment axis X. The illumination means () is capable of movement relative to the illumination axis Y so that the beam of light reflected by the beamsplitter () towards the pupil () is substantially the same size as the pupil () to maximize the amount of light entering the pupil without impinging upon the iris to avoid contracting of the pupil ().

Opthalmic camera and opthalmic camera adaptor

Provided is a multi-purpose imaging apparatus () comprising a body () and imaging means () housed within the body (). The body () is adapted to releasably engage an adaptor (). The adaptor () has an aperture () extending therethrough that aligns with the optical axis (X) of the imaging means () when so engaged, such that at least a portion of the optical axis (X) is not obscured. The adaptor () also has optics for illuminating a subject within the optical axis (X) for diagnostic purposes.

Multi-purpose imaging apparatus and adaptors therefor

Provided is an ophthalmic camera comprising: a camera having a camera lens; at least one illumination means; and an ophthalmic lens. The centres of the ophthalmic lens and camera lens are aligned to form an alignment axis. The at least one illumination means is capable of linear movement along a radial axis of the camera lens and pivotal movement about the radial plane incorporating radial axis and alignment axis. In such a manner, the circle of light emitted by the at least one illumination means is constantly directed to the centre of the ophthalmic lens.

Ophthalmic camera, ophthalmic camera adaptor and methods for determining a haemoglobin and glucose level of a patient

A portable slit-lamp apparatus, including a body () able to be held in the hand of an operator and a solid state lamp means () and associated optics () carried by the body for generating a narrow beam of light and projecting the beam onto the cornea of a patient s eye for reflection by structures of the eye, when the body is held at a suitable position in front of the eye. Means () is mounted in cooperation with the body and the solid state lamp means to detect a reflection of the narrow beam of light by structures of the eye and to make an image thereof, which image is, or is processable to provide, a digital record of the reflection.

Portable slit lamp

Disclosed is a method of insertion of keratoprostheses, and in particular, a method of surgical insertion and placement of a soft hydrogel prosthetic corneal device into the host cornea. The method of the invention provides a greatly improved rate of success for the implantation and retention of the device.

Method of insertion of keratoprostheses

The invention provides an ocular socket prosthesis comprising a hydrogel consisting essentially of a biocompatible hydrophilic polymer onto which tissues can be directly sutured. Preferably the prosthesis comprises the polymer both in its homogeneous gel form and in its sponge form, and the two forms are chemically joined at their interface via an interpenetrating polymer network (IPN). However, it is also contemplated that the prosthesis of the invention may be made predominantly or entirely from the sponge form of the polymer. Methods of production of the prosthesis of the invention and of surgical implantation are also disclosed and claimed.

Ocular socket prosthesis

A system (,) for ocular ultramicrosurgery a ring (,) for immobilising eye (,) of a patient. The incision point (P) on the eye (,) for surgical tools is marked by a marker (,) that is generated by intersecting tire beams of lasers (,and,). The intersection point of the laser beams is fixed in space. In order to move the patient's eye (,) so that point (P) coincides with that fixed point in space, the patient's head (,) is fixed to a head positioner (,). The head positioner is operated by a surgeon (,) through joystick (,) and computer (,) to ensure registration of point (P) and the point designated by the intersecting laser beams. All surgical tools used in the system (,) are supported, positioned and operated or worked by a tool support and positioning system (,). The system (,) comprises a stereotactic manipulator (,) and a tool translation table (,) which is supported on the manipulator (,). The manipulator (,) is used to position a surgical tool (,) on table (,) so that tip (,) of the tool (,) can be aligned with point (P). Thereafter, the manipulator (,) and/or table (,) can separately or in combination be used to pivot the tool (,) about point (A) so that the tip (,) of the tool is positioned at any desired location within the eye and subsequently worked or operated to perform ultramicrosurgery. Surgeon (,) is able to control the manipulator (,) and table (,) via computer (,) and input devices such as joysticks (,) and keyboard (,). In this way, the surgeon's hands are isolated from the movement of the tool (,).

System for ocular ultramicrosurgery

A composite device which may be implanted in the cornea of the human eye to replace damaged or diseased portions, and a method of manufacturing the said device, are disclosed. The device consists of a transparent central portion intimately attached to an opaque spongy rim. Both portions are made of hydrogel materials produced in different conditions of polymerization during a two-stage process performed in a specific moulding unit. The spongy rim promotes and maintains cellular invasion from the host corneal tissue, thus providing a tight union between implant and recipient cornea which prevents the postoperative extrusion of the implant.

Method of producing a keratoprosthesis

Keratoprosthesis

A method of making pigmented hydrophilic polymers in such a manner that the resulting polymers absorb ultraviolet and visible radiation, and that no migration, separation or leaching of the pigment can take place, is disclosed. The polymer compositions comprise blends of hydrophilic polymers with melanin pigments, the latter being synthesized on the hydrophilic polymer matrix. The disclosed polymer compositions are useful in the manufacture of ocular devices, particularly intraocular lenses and aphakic contact lenses capable of absorbing ultraviolet and visible radiation, at wavelengths between 300 and 700 nanometers, to the same extent as the natural crystalline lens of the eye. The disclosed method is also useful to impart photoprotective properties to the already made said ocular devices.

Growing community of inventors

Mosman Park, Australia

Ian J Constable