University of London

Other

Ian Graham

John George Dickson

Linda Popplewell

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Oligomers

There is described a handle, for example a door handle, lifting handle or touch pad, which is particularly useful as a self-sterilizing door handle for use in public areas. The handle comprises: a contact area formed of a hydrophilic sintered porous material, particularly a plastic material; and a reservoir containing an anti-microbial liquid, wherein said reservoir is fluidically connected to the contact area. The reservoir can include a port to allow the reservoir to be re-filled or alternatively the whole reservoir can be detached and replaced when required. The anti-microbial liquid can be delivered along the hydrophilic sintered porous material by fluid transmission action so that the contact area is continually treated by the anti-microbial liquid, thereby rendering the handle continuously wetted and disinfected and inhibiting the growth of culture forming units.

Growing community of inventors

Cambridge, United Kingdom

Ian Graham