Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Ian Frank Cottrell

Michael Stewart Ashwood

Ulf H Dolling

David Hands

Mark Cameron

Robert Darrin Wilson

Brian Christopher Bishop

John M Williams

Ronald B Jobson

Karel M Brands

Antony J Davies

Joseph E Lynch

Joseph F Payack

David L Hughes

Stephen Philip Keen

Andrew William Gibson

Dongwei Cai

David R Lieberman

Antony John Davies

Cameron Cowden

Gavin William Stewart

Karel Marie Joseph Brands

Cameron John Cowden

John Simon Edwards

Brian Cchristopher Bishop

Ramon John Alabaster

Guo Jie Ho

Yao Jun Shi

Debra Jane Wallace

Brian Christopher Bishops

Simon Adrian Johnson

Khateeta Moneek Emerson

The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as &#x3b1;&#x3bd;&#x3b2;3 receptor antagonists 

&#x3b1; v integrin receptor antagonists

The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.

Process for preparing peptide intermediates

Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis

The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.

Chemical synthesis of 1,2,4-triazolinone derivative

Chemical synthesis of morpholine derivatives

The present invention relates to a process for the preparation of substantially pure N-((S)-(-)-.alpha.-methylbenzyl)-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one hydrochloride, which comprises selectively crystallising the (S,S)-diastereomer as the hydrochloride salt from a mixture of the (S,R)- and (S,S)-diastereomers in an organic solvent, and collecting the resultant crystalline product.

Chemical synthesis of a chiral 1,4-oxazin-2-one

A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.

Process for synthesizing carbapenem side chain intermediates

The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R.sup.1 is a C.sub.1-6 alkyl or arylC.sub.1-4 alkyl group; and R.sup.2 is a hydrogen atom, a halogen atom, or a group selected from C.sub.1-6 alkyl, CF.sub.3 or C.sub.1-6 alkoxy substituted by C.sub.1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

Chemical synthesis of 1,4-oxazin-2-ones

The present invention is directed to a process for the preparation of the reagent dimethyl titanocene (Cp.sub.2 Ti(CH.sub.3).sub.2) from titanocene dichloride (Cp.sub.2 TiCl.sub.2) and a methyl magnesium halide, in particular, methyl magnesium chloride (CH.sub.3 MgCl). The instant process provides the desired reagent in a manner which is generally less hazardous and more economical than previous methods.

Process for the preparation of dimethyl titanocene

The present invention relates to a process for the preparation of azaindole derivatives of the formula ##STR1## wherein Q is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, hydroxy, aryl or arylC.sub.1-4 alkyl;

Chemical synthesis of azaindoles

The present invention provides a process for the preparation of substantially pure N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one which comprises:

Chemical synthesis of a chiral oxazinone

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Hertford, United Kingdom

Ian Frank Cottrell