University Health Network

Ian E Crandall

Walter A Szarek

Jason Z Vlahakis

Jeffrey Charuk

Reinhart Reithmeier

Kevin C Cain

The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by aorparasite in a subject in need thereof. The triazolium and imidazolium salts are compounds of the Formula (I) or (II): wherein R-R, R-R, R-R, X, X', X&#x2033;, Y, Y&#x2032; and Y&#x2033; are as defined in the disclosure. 

Triazolium and imidazolium salts and uses thereof

According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipient, or diluent. According to a second aspect of the invention, a composition for the prevention or treatment of malaria is provided. The composition comprises a pharmaceutically effective amount of a quinoline in combination with a surfactant, such as NPE, for reversing malarial resistance to quinolines. According to a third aspect of the invention, a method of preventing or treating malaria in a person is provided. The method comprises administering to a patient in need thereof one or both of the compositions described above.

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North York, Canada

Ian E Crandall