Beecham Group Plc

Smithkline Beecham Corporation

Ian David Normansell

John Edward Hodgson

Alison Jane Earl

Donald Bruce MacMichael

David Drake

Stephen Adrian Arlington

John Kenneth Addicott

John Spencer Stovold

Martin Karl Burnham

Moira Sloan Divers

Martin Karl Russel Burnham

Martin Karl Rossel Burnham

DNA sequences obtained fromATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin &#x3b2;-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.

Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for &#x3b2;-lactam antibiotic biosynthesis

Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression

DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin .beta.-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.

Chromosomal DNA fragments encoding enzymes for encoding .beta.-lactam

DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulanic acid and may be used to improve the yield of clavulanic acid produced by clavulanic acid-producing organisms such as S. clavuligerus ATCC 27064.

DNA molecules and vectors encoding clavulanic acid biosynthesis enzymes

Process and apparatus for cell sorting

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Worthing, United Kingdom

Ian David Normansell