Glaxo Laboratories Limited

Beecham Group Plc

Beecham Group P.1.c.

Ian D Fleming

David Noble

Wilfred F Wall

Stephen J Brewer

Hazel M Noble (formerly Gillett)

Michael K Turner

Hazel M Noble Formerly Gillett

Hazel M Noble

The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]-heptane -2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

Pure salts of clavulanic acid, e.g. lithium clavulanate

The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]heptane- 2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

Pure sodium salt of clavulanic acid

Pure potassium salt of clavulanic acid

A novel O-transcarbamoylase enzyme and its use in preparing a variety of 3-carbamoyloxymethyl cephalosporins from 3-hydroxymethyl cephalosporins and carbamoyl compounds are described.

O-Transcarbamoylase

Process for the purification of clavulanic acid

Method for producing cephalosporins

Growing community of inventors

Chalfont St. Peter, United Kingdom

Ian D Fleming