University of Illinois

Sru Biosystems, Inc.

Ian D Block

Brian T Cunningham

Nikhil Ganesh

Patrick C Mathias

Leo Li-Ying Chan

Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

Fluorescence detection enhancement using photonic crystal extraction

Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. The biosensors feature a tightly confined resonant electric field at the surface of this biosensor and provide a high surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio

The invention provides sensor compositions and method of making sensors.

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Champaign, IL, United States of America

Ian D Block