Merck Sharp + Dohme Corp.

Ian Churcher

Timothy Harrison

Matthew G Stanton

Alan John Nadin

Martin Richard Teall

Duncan Edward Shaw

Sonia Kerrad

Andrew Pate Owens

Paul Joseph Oakley

Susannah Williams

Brian John Williams

Kevin Dinnell

Jose Luis Castro Pineiro

Michela Bettati

Susannah William

Andrew Madin

Tamara Ladduwahetty

Kevin John Merchant

Timothy Jason Sparey

Alexander Richard Guiblin

Joanne Thomson

Amanda Louise Boase

Adam Smith

Sonia Kerrard

Abdul Quddus

Victoria Alexandra Doughty

Emmanuela Nizi

Jonathan David Wrigley

Dirk Beher

Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of A&#x3b2; in the brain.

(4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease

Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of &#x3b3;-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma-secretase

Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma secretase

Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease. 

Gamma-secretase inhibitors

Novel sulphones of formula I are disclosed:  The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones

A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by &#x3b3;-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of &#x3b2;-amyloid, such as Alzheimer's disease 

Benzodiazepine derivatives as APP modulators

Compounds of formula I: wherein Arand Arare optionally substituted aryl or heteroaryl, L is a bond, &#x2550;CH&#x2014; or &#x2014;(CHR)&#x2014;, and X is SCN, SR, S(O)R, (CRR)SOR, SON(R), SONHCOR, SONHN(R), OSON(R, OS(O)N(R), OSONHCOR, COR, NHCOR, NHCOR, NHCON(R), NHSORor NHSON(R), inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.

Benzodiazepine derivatives as inhibitors of gamma secretase

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Compounds of formula I:inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

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Great Dunmow, United Kingdom

Ian Churcher