Massachusetts Institute of Technology

Leuko Labs, Inc

Universidad Politécnica De Madrid

Consejo Superior De Investigaciones Cientificas

Fundacion Para El Conocimiento Madri+d

Ian Butterworth

Carlos Castro-Gonzalez

Alvaro Sanchez Ferro

Aurelien Bourquard

Luca Giancardo

Carlos Sanchez Mendoza

Tom Vettenburg

Alvaro Sanchez-Ferro

Alberto Pablo-Trinidad

Carlos Castro Gonzalez

Maria J Ledesma Carbayo

Ganimete Lamaj

Nolan Bell

Alberto Pablo Trinidad

Jason Tucker-schwartz

Brian W Anthony

Luca Daniel

Luis Elvira Segura

Jason Michael Tucker-Schwartz

Francisco Montero

John Lee Haeseon

Ramon Martinez De Sarasa Pardas

Cedric Gobber

Petra B Krauledat

William Peter Hansen

Ryan Benasutti

Oscar Martinez Graullera

Shiva Kant Shukla

Maria J Ledesma-Carbayo

Javier Jimenez

Maria J Ledmesma-Carbayo

Carlos Castro-Gonzales

A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.

Finger inserts for a nailfold imaging device

A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Systems, devices and methods for non-invasive hematological measurements

In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

Method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos

An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed.

Automated system for acquiring images of one or more capillaries in a capillary bed

A system and method for measuring a hydration level in human tissue. The system includes a coaxial probe have a first end configured to be in contract with human tissue and configured to be emit and receive signals associated with a spectroscopic technique and having a second end adapted to be coupled to transmit and receive circuitry. The system further includes a patch or other means coupled to the coaxial probe and configured to be adhered to human tissue so as to provide a force upon at least a portion of the coaxial probe configured to be in contact with human tissue. In embodiments, the system may further include means coupled to receive signals from the coaxial probe, for determining an amount of liquid within a portion of human tissue in contact with the first end of the probe.

Non-invasive skin contact sensor

Non-invasive white blood cell monitoring device

Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.

Apparatus and method for motor function characterization

The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Method for detecting circulating cells in superficial body fluids

Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.

Systems, apparatus, and methods for analyzing blood cell dynamics

Growing community of inventors

Cambridge, MA, United States of America

Ian Butterworth