Novartis Ag

Coopervision International Holding Company, LP

Coopervision International Limited

Monsanto Company

Shell Research Limited

Irm LLC

Novartis Pharma Gmbh

Ian Bruce

Bernard Cuenoud

David Robert Morsley

David Beattie

Edyta S Bialek

Lee Darren Norris

Robin Alec Fairhurst

Neil Goodenough

Robert Oag

Graham Charles Bloomfield

Sarah L Almond

Judy Fox Hayler

Andrew James Culshaw

Richard C Rogers

George W Fleet

Clive McCarthy

Catherine Howsham

Simon James Watson

Emma Budd

James Neef

Pascal Furet

Stephen Paul Collingwood

Vince S Yeh

Jon Christopher Loren

Lee Edwards

Catherine LeBlanc

Sylvie Chamoin

Louise Clare Kirman

Duncan Shaw

Gregory John Hollingworth

Rachel Marullo

Vikki Furminger

Philip A Brame

Robin Frith

Sarah Lewis

Nicola Press

Alex Michael Saunders

Mrinalini Sachin Oza

A K M Shahab Siddiqui

Benjamin Richard Bellenie

Benjamin S Sheader

Matthew Spendiff

Geoffrey A Blyth

Gregg A Dean

Brian Cox

Darren Mark Le Grand

Edward Charles Hall

Darren Mark Legrand

Thomas Anthony Hunt

Christopher Thomson

Thomas Hugo Keller

Percy Lazon De La Jara

Lewis Whitehead

Lilya Sviridenko

Peter Finan

Sarah E Darnton

Pete Coldrey

Jamie Snell

Diana Janus

Stuart Bailey

Stephen Saunders

Ryan West

Lena Shukla

Eve Blyth, Legal Representative

Mark S Baird

Valentina Molteni

Charlie Chen

Catherine Leblanc

David Andrew Sandham

Roger John Taylor

Neil John Press

Jeffrey McKenna

Thomas Ullrich

Clive Mccarthy

Andrew Dunstan

Katharine Louise Turner

James Dale

Nicholas James Devereux

Victoria Tran

François Gessier

Christopher G Thomson

Amarylla Horvath

Cathy Ritchie

Anny-Odile Colson

Akm Shahab Siddiqui

Gaynor Elizabeth Pilgrim

Barbara Valade

Adam Fieldhouse

Gabriele Weitz Schmidt

David M Radcliffe

Lin Lv

Valentina Molten

Roy Maxwell Turner

Valentia Molteni

Thomas Sharp

Lewis Whithead

Gaynor Elizabeth Woodward

Helen Elizabeth Oakman

Reamonn Madden

The present disclosure relates to a membrane () suitable for forming at least part of a contact lens () by bonding to a bulk lens portion (). The membrane has a central axis (). The membrane comprises: a first face (); a second face (); and a peripheral edge (). In a cross-sectional plane passing through and parallel to the central axis of the membrane, the thickness () of the membrane is at least 10 microns at a distance of 60 microns from the peripheral edge. The present disclosure also relates to a contact lens (). The contact lens comprises a membrane (), a bulk lens portion (), and a bonding interface () between at least part of the membrane and at least part of the bulk lens portion. The present disclosure also relates to a method of manufacturing a contact lens.

Contact lens membrane and related methods

A method of designing a fluid-filled contact lens () is described. The method involves generating a computational model that includes a fluid-filled lens () and the shape of a cornea causes deformation of an internal structure of the fluid-filled lens () to generate a deformed, fluid-filled lens () with altered optical properties. The method also includes modelling () the optical properties of the deformed, fluid-filled lens (). The shape of the fluid-filled lens () is then adjusted () to reduce the effects of the deformation on the optical properties. This is referred to as an adjusted fluid-filled lens (). A corresponding off-eye lens design is generated (based on the adjusted fluid-filled lens design.

Method of designing a fluid-filled contact lens

The present disclosure concerns a tuneable ophthalmic lens. The tuneable ophthalmic lens comprises an activated state and a deactivated state. The ophthalmic lens further comprises a central chamber. The ophthalmic lens also comprises a fluid reservoir, the fluid reservoir being in fluid communication with the central chamber. The fluid reservoir comprises a pump for pumping fluid between the fluid reservoir and the central chamber. In the deactivated state the central chamber is substantially empty of fluid. In the activated state the central chamber is not substantially empty of fluid.

Tuneable ophthalmic lens

Methods and apparatus for making lens assemblies that can be placed on an eye of a person and that include at least one component are described. Generally, a first lens member () and a second lens member () are formed. The second lens member () is transferred to a compliant stage (). At least one component is placed in contact with one of the lens members (). The second lens member () is placed in contact with the first lens member () such that the compliant stage () can provide compression to the first and second lens members (). The second lens member () and the first lens member () are coupled together to form a lens assembly () with the at least one component located between the two lens members ().

Methods and systems for making a lens assembly

Multilayer contact lenses and methods of making the same are described. A contact lens () includes a lens assembly (). The lens assembly () includes a plurality of flexible lens layers. A first layer () has a uniform or smooth anterior surface (), and a second layer () has a structured posterior surface that includes one or more recesses (). The anterior surface () of the first layer () and the structured posterior surface of the second layer () define a first cavity () for containing one or more components.

Multilayer contact lens

A tuneable contact lens (), wherein the contact lens comprises a central region (). The central region has a circumferential wall and an anterior surface having an external curvature. The contact lens also comprises an inflatable ring () arranged around the circumferential wall of the central region, and at least one fluid reservoir () in fluid connection with the inflatable ring. The at least one fluid reservoir comprises a pump. When fluid is pumped from the at least one fluid reservoir to the inflatable ring, the inflatable ring inflates and the external curvature of anterior portion of the central region is changed.

A method of manufacturing a contact lensis disclosed. The method comprises manufacturing a rod of lens material, the rodcontaining a plurality of electronic componentsspaced apart along its length, separating the rodinto a plurality of lens blanks, each lens blankcontaining at least one of said electronic components, and machining the front and/or back surface of a lens blankto produce a contact lenscontaining the at least one electronic component

Method of manufacturing contact lenses

Ophthalmic device molds made from a first portion of a molding surface formed from a first polymer and a second portion of the molding surface formed from a second polymer are described. When combined, the first portion and the second portion of the molding surface form an entire molding surface suitable for molding an entire surface, such as an anterior surface or a posterior surface of an ophthalmic device. Methods of manufacturing ophthalmic devices using these molds, including contact lenses, are also described.

Ophthalmic device molds and related methods

The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform. 

Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors

Ophthalmic device molds made from at least one water-soluble vinyl alcohol copolymer, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, packaged ophthalmic devices present in a solution comprising the at least one water-soluble vinyl alcohol copolymer, and related methods are described. The methods of manufacturing ophthalmic devices can use wet demolding processes, or wet delensing processes or both wet demolding and wet delensing processes involving dissolving the molds in water or an aqueous solution.

Ophthalmic device molds formed from water-soluble vinyl alcohol copolymer, ophthalmic devices molded therein, and related methods

Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors

Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors

A method for manufacturing a silicone hydrogel contact lens is described that comprises curing a polymerizable composition comprising at least one siloxane monomer and at least one hydrophilic vinyl-containing monomer in a contact lens mold comprising a molding surface having a coating comprising a hydrophilic polymer. The hydrophilic coating is not solubilized by the polymerizable composition during the curing step. The resulting polymeric lens body is removed from the mold, washed to remove any of the hydrophilic polymer that may have transferred from the mold surface to the lens during the curing or lens removal process, and packaged to provide a silicone hydrogel contact lens having a contact angle that is lower than what it would otherwise be had the lens been cured in the same contact lens mold lacking the hydrophilic coating.

Method of manufacturing wettable silicone hydrogel contact lenses

Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R, R, R, R, R, R, Rand X are as defined herein.

Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension

Ophthalmic lens molds made from at least one vinyl alcohol copolymers with high amorphous content, ophthalmic lenses including silicone hydrogel contact lenses formed using these molds, packaged ophthalmic lenses present in a solution comprising the at least one vinyl alcohol copolymer with high amorphous content, and related methods are described. The methods of manufacturing ophthalmic lenses can use wet demolding, delensing or demolding and delensing processes involving dissolving the molds in water or an aqueous solution.

Vinyl alcohol ophthalmic lens molds, ophthalmic lenses molded therein, and related methods

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Horsham, United Kingdom

Ian Bruce