Proximagen Limited

Astrazeneca Ab

Astrazeneca Ab (publ)

Iain Simpson

Edward Savory

Lee Patient

David Evans

Max Espensen

Michael Higginbottom

Allison Carley

Alison Stewart

Maurice Raymond Verschoyle Finlay

Sameer Pralhad Kawatkar

Scott Nathan Mlynarski

Tyler Grebe

Andrew Graham Cole

Kathryn Oliver

Dedong Wu

Steve Cook

Jianyan Wang

Giles Brown

Marianne Nilsson

Tobias Koolmeister

Martin Haraldsson

Stuart Norman Lile Bennett

Erik Nordling

Giles Albert Brown

Jason Grant Kettle

Kurt G Pike

Paul Robert Owen Whittamore

Richard Andrew Ward

Christopher Thomas Halsall

Scott Boyd

Rikard Emond

Paul Ro Whittamore

Doyle Joseph Cassar

Michael Steven Bodnarchuk

David Alan Rudge

Joseph W Boyd

Allison Powell

Oliver Ross Steward

Christopher Phillips

Viet-Anh Anne Horgan (Nee Nguyen)

Jaqueline Ouzman

Sofia Henriksson

Kurt Gordon Pike

Edward Daniel Savory

Viet-Anh Anne Horgan

Giles A Brown

Jacqueline Ouzman

Disclosed are compounds of formula (Ib) or (Vc), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ib) or (Vc) and methods of using the same for treating cancer, respiratory inflammatory disease, and inhibiting arginase; wherein Ris —H or —C(O)CH(R)NHR; and Ris selected from —H, —(C-C) alkyl and CHOR; Ris —H; or alternatively, Rand R, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and Ris H or —CH.

Arginase inhibitors and methods of use thereof

The specification relates to compounds of Formula (A) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Fused tricyclic compounds useful as anticancer agents

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof and the use of the same in therapy: wherein Z, Y, R, W, V, and Rare as defined in claim. 

Imidazo[4,5-C]pyridine derived SSAO inhibitors

Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R, and Rare as defined herein.

Substituted imidazo[4,5-c]pyridine compounds and compositions thereof

The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R, X, Y and Rare as defined in the claims.

CXCR4 receptor antagonists

A process for the preparation of a compound of formula (Ia) or a pharmaceutically acceptable salt, or N-oxide thereof that includes reacting a compound of formula (IIIa) or (Va) with a compound of formula (IX) to form the compound of formula (Ia) 

Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors

The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, Rand Rare as defined in the claims.

The present invention relates to compounds which are inhibitors of SSAO activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases, immune disorders and the inhibition of tumor growth.

Compounds

Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors

The compounds of formula (I) are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) activity useful in the treatment of inflammation, an inflammatory disease, an immune or an autoimmune disorder, or inhibition of tumor growth. 

Growing community of inventors

Cambridge, United Kingdom

Iain Simpson