Otivio As

Inovio As

Inovio Pharmaceuticals, Inc.

Genetronics, Inc.

Electrofect As

Iacob Mathiesen

Arnar Kristjansson

Hannes Ulvegard

Robert Axelsson

Ronny Brakhya

Jonas Elderstiern

Torunn E Tjelle

Juho Laasanen

Terje Lomo

Rune Kjeken

Knut Arvid Sorensen Rekdahl

Bjorn David-Andersen

George McHugh

Elisabeth Torunn Tjelle

Marius Andresen

Sanna Tuononen

Petri Rantanen

Andreas Erlandsen

Knut Arvid Sørensen Rekdahl

Bjøm David-Andersen

Stig Tollefsen

Joachim Rasmussen

Jakob Pettersen

Laura Anne Inman

Torunn Elisabeth Tjelle

Knut Arvid Rekdahl

A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.

Medical pressure therapy device and components thereof

An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.

Electroporation device and injection apparatus

Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

Device and method for single-needle in vivo electroporation

A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.

Method for muscle delivery of drugs, nucleic acids and other compounds

An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising:

A method is disclosed for enhanced vaccination and genetic vaccination of mammals. The vaccination is accomplished by delivering molecules such as proteins and nucleic acids into skeletal muscle and other cells residing in the skeletal muscle in vivo. The protein or nucleic acid is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.

Method for genetic immunization

Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells

A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The pharmaceutical drug or nucleic acid is first injected into the muscle at one or multiple sites. Immediately, or shortly after, injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.

Method for introducing pharmaceutical drugs and nucleic acids into

Growing community of inventors

Oslo, Norway

Iacob Mathiesen