National Taiwan University

Academia Sinica

I-Ju Liu

Han-Chung Wu

Chien-Yu Chiu

Ruei-Min Lu

Chiung-Yi Chiu

Yu-Ling Chang

An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

Anti-vascular endothelial growth factor receptor 2 (VEGFR2) antibody and methods of use thereof for detecting VEGFR2 and for inhibiting tumor growth, tumor angiogenesis and/or inducing cancer cell cytotoxicity

Disclosed is SARS-CoV-specific B-cell epitope and applications thereof. The epitopes are peptides and can either be expressed in phages or synthesized to diagnose SARS patients accurately. High sensitivity and specificity of the serologic detection are achievable by using a plurality of SARS-CoV-specific B-cell epitope-based peptides. Therefore, the peptides can be applied to SARS diagnosis and have potentials to be immunogens for producing antibodies against SARS.

SARS-CoV-specific B-cell epitope and applications thereof

Growing community of inventors

Taipei, Taiwan

I-Ju Liu