Methylation Sciences International Srl

Msi Methylation Sciences, Inc.

I David MacDonald

Robert Miller

Aniko Takacs-Cox

Nancy Harrison

Dechi Guan

Admir Purac

Almira Blazek-Welsh

Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.

Pharmacokinetics of S-adenosylmethionine formulations

Provided herein are compositions and formulations comprising S-adenosyl-L-methionine ('SAM-e' or 'SAMe') and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.

Compositions comprising S-adenosylmethionine and a gallic acid ester

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Surrey, Canada

I David MacDonald