Taiwan Hopax Chemicals Mfg. Co., Ltd.

University of Texas System

Taiwan Hopaz Chems, Mfg. Co., Ltd.

Taiwan Hopax Chemicals Manufacturing Company, Ltd.

Taiwan Hopax Chems. Mfg. Co., Ltd.

I-Chien Wei

Tsung-Tien Kuo

Hsieh-Chang Hsieh

David J Yang

Dong-Fang Yu

Ning Tsao

Kung-Hsing Lee

Hsien-Ming Hung

Meng-Hui Hsu

Shan-Ying Lin

Ya-Hui Huang

The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.

Glycopeptide compositions

This invention discloses chemically modified polyaminosaccharides, in particular chemically modified chitosans, in the molecular structure of which a predetermined proportion of the amino functional groups is sulfonated by the hydrocarbyl sultone compound via a covalent bond. Such chemically modified polyaminosaccharides may be produced by a process of sulfonating an un-modified polyaminosaccharide having amino functional groups by a hydrocarbyl sultone compound in the presence of an organic solvent under a suitable temperature. Chemically modified chitosans of this invention may be used in a variety of applications, including wound healing.

Chemically modified polyaminosaccharide by a hydrocarbyl sultone compound

The present invention pertains to a process for preparing clusters of infusible, inherently tacky, elastomeric, solvent-insoluble, solvent-dispersible polymeric microparticles by aqueous emulsion polymerization. The invention also pertains to an adhesive comprising the polymeric microparticles and to a repeatedly reusable pressure sensitive sheet material having the elastomeric microparticles coated thereon.

Process for making tacky acrylate microparticles and use therefor

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Kaohsiung, Taiwan

I-Chien Wei