University of California

Ligand Pharmaceuticals, Inc.

I Charles Pathirana

Todd Kevin Jones

Lawrence G Hamann

Luc J Farmer

William H Fenical

Christina S Berger

Robert B Stein

Michael G Johnson

Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.

Non-steroid progesterone receptor agonist and antagonist and compounds

Growing community of inventors

San Diego, CA, United States of America

I Charles Pathirana