University of Southampton

E Ink Corporation

The University of Western Australia

Secretary of State for Health and Social Care

Hywel Morgan

Stephen J Telfer

Richard J Paolini, Jr

George G Harris

William T Vetterling

Jay William Anseth

Craig A Herb

Alain Bouchard

Sunil Krishna Sainis

Lee Yezek

Luke M Slominski

Isaac W Moran

Randal M Hill

Matthew Charles Mowlem

Jennifer M Morrison

Xi Huang

Daniel Spencer

Ying Cheong

Daniel Christopher Spencer

Vincent Joseph Sieben

John Mark Sutton

Shilong Lu

Robin William Pascal

Jennifer Quimby

Randall M Hill

Iain Rodney George Ogilvie

Nick Macklon

Cedric Florian Aymeric Floquet

Charlotte Hind

Timothy John Jay Inglis

Teagan Paton

Kieran Mulroney

Riccardo Reale

Jr Richard J Paolini

An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another.

Method for driving two layer variable transmission display

A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.

Impedance flow cytometry methods

Impedance flow cytometry apparatus comprises: a flow channel for carrying a flow of fluid comprising particles suspended in an electrolyte from an inlet to an outlet; a first electrode group and a second electrode group, each electrode group providing first and second current paths through fluid flowing in the flow channel; wherein each electrode group comprises: a first signal electrode to provide to the first current path a first electrical signal of frequency, magnitude and phase; a second signal electrode to provide to the second current path a second electrical signal of substantially equal frequency and magnitude as the first electrical signal and of opposite phase to the first electrical signal; and one or more measurement electrodes to detect current flow in the first current path and the second current path and produce a summed signal representing the sum of the current flow in the first current path and the current flow in the second current path; wherein the first electrode group produces a first summed signal and the second electrode group produces a second summed signal; and circuitry to determine a differential signal representing the difference between the first summed signal and the second summed signal.

Impedance flow cytometry apparatus

A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.

Wearable antenna and intra-uterine monitoring system

An intra-uterine monitoring system is described. The system comprises an implantable sensor device, shaped and dimensioned for implantation in a uterus for measuring conditions within the uterus to generate sensor data, and a wearable receiver device, for wirelessly receiving the sensor data generated by the implantable sensor device. In this way, real-time, in-vivo monitoring of the intra-uterine environment can be performed. The implantable sensor device can be kept small and simple, requiring only the mechanical and electronic structures necessary to take sensor measurements and transmit those to the receiver device. By making the receiver device wearable, it can be kept in relatively close proximity to the implantable sensor device on a long-term basis, making regular monitoring viable.

Intra-uterine monitoring system

A method of electrically measuring the electrical properties of individual particles flowing in a liquid, which method comprises: (i) providing apparatus () which is for electrically measuring the individual particles and which has: (a) a fluidic channel () for receiving a liquid () having the individual particles () in suspension in the liquid (); (b) a first electrode arrangement () having at least one measurement electrode () and at least one signal electrode (); and (c) at least one other electrode arrangement () having at least one measurement electrode () and at least one signal electrode (); (ii) providing a flow of the liquid () through the fluidic channel (); (iii) applying a first electrical signal through the liquid () and along a first conduction path between the measurement electrode () and the signal electrode () of the first electrode arrangement (); (iv) applying an electrical signal through the liquid () and along at least one other conduction path; (v) comparing the electrical signal between the first and the other conduction paths to generate a comparison signal; (vi) detecting an individual particle passing through the apparatus () by detecting a feature of the comparison signal of the individual particle, and obtaining at least one output waveform; (vii) measuring a height-related feature of the output waveform of the individual particle, and generating a first order assessment of the electrical properties of the individual particle; and (viii) assessing the shape of the output waveform to perform a second order adjustment to the first order assessment of the electrical properties of the individual particle, with the second order adjustment utilising data on a perceived degree of error in the first order assessment based on information on a known relationship between the waveform shape and the error in the first order assessment.

Method of electrically measuring the electrical properties of individual particles flowing in a liquid

Apparatus () for electrically measuring individual particles () flowing in a liquid (), which apparatus () comprises: (i) a fluidic channel () for receiving a liquid () having the individual particles () in suspension in the liquid (); (ii) a first electrode arrangement () having at least one measurement electrode () and at least one signal electrode (); (iii) at least one other electrode arrangement () having at least one measurement electrode and at least one signal electrode (); (iv) at least one signal conditioning electrode () positioned adjacent to at least one of the measurement electrodes () or at least one of the signal electrode (); and (v) measuring means () for measuring electrical signal changes; and the apparatus () being such that: (vi) the first and the other electrode arrangements () are connected to the measuring means () whereby individual particles passing between the first and other electrode arrangements () cause a change in electrical signal which is measured; and (vii) the electrical potential of the signal conditioning electrode () is controlled to substantially prevent current flow between the first electrode arrangement () and the other electrode arrangement ().

Apparatus for electrically measuring individual particles flowing in a liquid

Multi-color electro-optic displays

Apparatus () for sensing at least one parameter in water, which apparatus comprises: (i) a conductivity sensor () for sensing conductivity in the water; (ii) a dissolved oxygen sensor () for sensing dissolved oxygen in the water; (iii) a glass substrate (); and (iv) the conductivity sensor () and the dissolved oxygen sensor () are fabricated on the glass substrate () using photolithography and etching.

Apparatus for sensing at least one parameter in water

Apparatus () for sensing at least one parameter in water, which apparatus () comprises: (i) a conductivity sensor () for sensing conductivity in water; (ii) the conductivity sensor () is an electrode-based conductivity sensor having bare electrodes () which contact the water; (iii) there are at least four of the electrodes (); (iv) the conductivity sensor () is fabricated on a substrate () using photolithography and etching; (v) the conductivity sensor () is an open cell sensor having a physically unconstrained electric field; (vi) the conductivity sensor () is of a dot construction comprising a dot and a surrounding formation; (vii) the conductivity sensor () has two electrodes which are for current stimulation and which geometrically bound and enclose another two electrodes which are for voltage sensing; and (viii) the conductivity sensor () is a laminar construction on the substrate ().

Apparatus () for sensing at least one parameter in water, which apparatus () comprises: (i) at least one electrode based sensor () for sensing at least one parameter in water; and which apparatus () is such that: (ii) the electrode based sensor () has a self-cleaning electrode; (iii) the electrode based sensor () has a reference electrode; (iv) the self-cleaning electrode is stable in water; (v) the apparatus () is configured to operate by liberating chlorine from the water using a first waveform applied to the self-cleaning electrode; (VI) the apparatus () is configured to operate by liberating chlorine and oxygen from the water using a second waveform applied to the self-cleaning electrode; and (VII) the apparatus () is configured to preserve the condition of the reference electrode by periodically regenerating the reference electrode.

Apparatus with a self-cleaning electrode for sensing at least one parameter in water

Apparatus () for sensing at least one parameter in water, which apparatus () comprises: (i) a dissolved oxygen sensor () for sensing dissolved oxygen in the water; and which apparatus () is such that: (ii) the dissolved oxygen sensor () has a working electrode and a reference electrode; and (iii) a voltage signal is applied between the working electrode and the reference electrode, and the voltage signal provides a conditioning waveform, then a wait time, and then a measurement function.

Process for sensing at least one parameter in water

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Southampton, United Kingdom

Hywel Morgan