University of Illinois

Purdue Research Foundation

Hyunjoon Kong

Rashid Bashir

Vincent Chan

Chaenyung Cha

Pinar Zorlutuna

Yongbeom Seo

Byoungsoo Kim

Jaehyun Jeong

Chi Hwan Lee

Min Ku Kim

Jiayu Leong

Jonghwi Lee

Ryan Cree Miller

Yu-Heng Deng

Yu-Tong Hong

Youngjun Kim

Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.

Electrothermal manipulator

Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.

Catalytic microgelators for decoupled control of gelation rate and rigidity of biological gels

Compositions comprising an active oxygen-responsive antioxidant crystal, methods of making them, and methods for controlling the dissolution rate and/or altering the crystallization behavior of an antioxidant are disclosed. The crystals comprise an antioxidant and a disulfide- or diselenide-crosslinked polymer that is adsorbed onto a surface of the antioxidant. Upon exposure to an active-oxygen stimulus, the polymer de-crosslinks to release the antioxidant from the composition in an amount effective to counteract the stimulus. While prior approaches to altering dissolution rates have relied on passive zero- or first-order kinetics that are independent of ROS levels, the inventive compositions actively respond by releasing antioxidant in an amount proportional to the concentration of active-oxygen species present. The crystallization methods are simple and scalable. The antioxidant balances ROS concentration and allows formulators of nutritional supplements, drug therapies, and other applications to more effectively use antioxidants while avoiding undesirable levels of antioxidative stress.

Stimulus-responsive antioxidant crystals and method for their preparation

Diatom microbubblers comprising diatom biosilica or other silica linked to a catalyst for the decomposition of hydrogen peroxide, such as manganese oxide (MnO), platinum (Pt), CuO (copper II oxide), or zinc peroxide (ZnO) particles or nanosheets, or catalase are provided. Further provided are methods of reducing or eliminating biofilm or biofouling conditions.

Diatom microbubbler for biofilm removal

The invention provides compositions and methods for making and using microvascular stamps for stimulation and spatial organization of neovessels in tissue.

Microvascular stamp for patterning of functional neovessels

Growing community of inventors

Champaign, IL, United States of America

Hyunjoon Kong