Yonsung Fine Chemical Co., Ltd.

Ys Life Science Co. Ltd.

Hyunik Shin

Changyoung Oh

Hyoseon Lee

Areum Baek

Keeyoung Lee

Seung Woo Kim

Yongseo Park

Seunghui Sin

Eunim Jeong

Seongtaek Kim

Se Gyo Jung

In A Jung

Provided is a novel crystalline form of lifitegrast and a pharmaceutical composition containing the novel crystalline form of lifitegrast. The crystalline form of lifitegrast has improved solubility and excellent stability against heat and moisture, thereby being effectively used for preparing a pharmaceutical composition.

Crystalline form of lifitegrast, and pharmaceutical composition comprising the same

An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.

Crystalline salt of eribulin

A new and improved method for preparing maxacalcitol and an intermediate therefor is provided. The method is an efficient and cost-effective process for preparing maxacalcitol and an intermediate therefor.

Method for producing maxacalcitol, and intermediate therefor

Provided is a cost-effective process for preparing naldemedine having high purity with high yields.

Method for preparing naldemedine

The present invention relates to a process for preparing a compound of formula (6) which is an intermediate for the preparation of eribulin mesylate with high yields and high purity, and an intermediate therefor.

Intermediate for preparing eribulin mesylate and process for preparing the same

The present invention relates to a process for preparing an intermediate for the preparation of eribulin mesylate with high yields, and an intermediate therefor.

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Suwon-si, South Korea

Hyunik Shin