Postech Academy-industry Foundation

Posco

Postech Foundation

Posco Co., Ltd

Postech Research and Business Development Foundation

Curearth, Inc.

Nature Gluetech Co., Ltd.

Hyung Joon Cha

Dong Soo Hwang

Yoo Seong Choi

Yun Kee Jo

Chang Sup Kim

Jeong Hyun Seo

Dong Gyun Kang

Kye Il Joo

Bong-Hyuk Choi

Jung Ho Lee

Hoon Cho

Yeon Su Jeong

Geun Bae Lim

Eun Young Jeon

Hyo Jeong Kim

Yun Jung Yang

Bum Jin Kim

Yeonsu Jeong

Oh-Gi Jung, Legal Representative

Young Soo Gim

Seonghye Lim

Young Hoon Song

Hyungdon Yun

Byeongseon Yang

Hwahui Shin

Byung Hoon Jo

Im Gyu Kim

Ho Gyun Cheong

Changsup Kim

Hogyun Cheong

Seung Ho Baek

Sun Jong Yu

Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

Microneedle adhesive patch based on hydrogel formulation

Disclosed are a bio-responsive adhesive antibody delivery platform for immunotherapy, use thereof, and a preparation method thereof. The bio-responsive adhesive antibody delivery platform for immunotherapy according to the present disclosure may enhance a retention time of the antibody at a target site via adhesiveness of the delivery platform and may selectively release the antibody in response to specific enzymes to efficiently deliver the antibody.

Bio-responsive adhesive antibody delivery platform for immunotherapy and preparation method thereof

The present invention relates to: a photothermal agent which includes a mussel adhesive protein; and photothermal-responsive nanoparticles that generate a biocompatible gas by means of light and heat and release a drug. Nanoparticles according to the present invention exhibit a photothermal effect when near-infrared rays are applied thereto, and may be applied to trimodality therapy in which a biocompatible gas is generated by means of light and heat to induce the release of a drug.

Mussel adhesive protein-based photothermal agent and photothermal-responsive adhesive nanoparticles

A coacervate including a catechol-substituted anionic polymer; an adhesive including same; and a method for producing the coacervate are described. More specifically, a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive including the coacervate; and a method for producing a coacervate are described. The method includes a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

Coacervate formed from catechol-substituted anionic polymer, adhesive comprising same, and method for producing same

An antimicrobial adhesive protein, an antimicrobial nanoparticle, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition are described and, more particularly, an antimicrobial adhesive protein in which an antibiotic peptide is linked to a mussel adhesive protein, a mussel adhesive protein derivative of which a tyrosine residue within the antimicrobial adhesive protein is modified with a catechol derivative, an antimicrobial nanoparticle including a metal capable of forming a coordinate bond with a derivative of the mussel adhesive protein and having intrinsic antimicrobial activity, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition are described.

Antimicrobial adhesive protein, antimicrobial nanoparticle, antimicrobial composition comprising same nanoparticle, and preparation method for same composition

The present disclosure relates to a composition for the destruction of microalgae or mosses. The composition for the destruction of microalgae or mosses may suppress the growth and proliferation of microalgae when treated in moss cultivation facilities, marine microalgae cultivation facilities, areas in which green or red tide is occurring, or areas in which green or red tide is expected to occur, thereby preventing damage caused by the green or red tide.

Composition for destruction of microalgae or sphaerocarpus

The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Mussel-inspired bioactive surface coating composition generating silica nanoparticles

The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.

PH-responsive nanoparticle using mussel adhesive protein for drug delivery and method for preparing the same

There are provided a recombinant silk protein derived from sea anemones, a method for producing the same, and a composition for preparing a silk fiber including same. The recombinant silk protein derived from sea anemones has sequence features similar to genetic information of a silk protein derived from spiders and silkworms. Also, a large amount of recombinant silk protein derived from sea anemones may be produced from a transformant and it has good physical properties such as strength and elasticity. Therefore, the recombinant silk protein derived from sea anemones can be usefully applied in various industrial fields in which natural silk protein can be applied, and it is expected to create new industrial fields based on its distinctive mechanical properties.

Recombinant silk protein derived from sea anemones, method for manufacturing same, and composition for manufacturing silk fibers including same

The present invention relates to a technique for capturing carbon dioxide and converting the carbon dioxide to carbonate minerals using a recombinant whole cell biocatalyst expressing carbonic anhydrase. More particularly, the present invention relates to a composition for capturing carbon dioxide and a method for capturing carbon dioxide using the composition, which composition comprises a whole cell of a transformant formed with a vector including a nucleic acid encoding a recombinant carbonic anhydrase; a cell lysate or its fraction of the whole cell; or a recombinant carbonic anhydrase isolated from the whole cell. Further, the present invention relates to a composition and method for converting the carbon dioxide to carbonate minerals using the carbon dioxide capturing composition.

Method for converting and producing carbonate minerals from carbon dioxide using recombinant biocatalyst

The present invention relates to a novel fusion protein comprising Staphylococcal protein A and mussel adhesive protein, a biochip comprising a solid substrate to which the fusion protein is attached, and a method for detecting a target antigen in a biological sample using the biochip. Furthermore, the present invention relates to a polynucleotide encoding the fusion protein, a recombinant vector comprising the polynucleotide, a transformed cell comprising the recombinant vector, and a method of preparing the fusion protein by transformed cell comprising the recombinant vector.

Immobilizing fusion protein for effective and oriented immobilization of antibody on surfaces

The present invention related to a saccharide-based cholera toxin detection sensor for detection ofand its use. More specifically, the present invention relates to a carbohydrate chip for detection of, a method for detectingusing the same, and a method for preparing the same, where the carbohydrate chip comprises GM1 pentasaccharide, GM2 tetrasaccharide, asialo GM1 tetrasaccharide, GM3 trisaccharide, galactose-&#x3b2; 1,3-N-acetylgalactosamine, lactose, and sialic acid that are immobilized on the surface of a solid substrate.

Carbohydrate chip for detection of pathogen Vibrio cholerae and method of preparing the same

The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More specifically, the present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is incorporated instead of a tyrosine residue, and a method for producing the same, and a transformant for producing the recombinant mussel adhesive protein.

Method for in vivo residue-specific DOPA incorporation into mussel adhesive proteins

The present invention relates to a coacervate comprising a mussel adhesive protein and an anionic polymer, and more particularly, to a coacervate prepared by mixing a mussel adhesive protein with an anionic polymer, and a novel use thereof. In the present invention, a coacervate prepared by mixing a mussel adhesive protein and an anionic polymer shows a very excellent adhesive strength to various substrates such as cells or metals, and is able to maintain its adhesive strength in the presence of water or under water, thereby being effectively used as an adhesive. Moreover, it has an activity capable of encapsulating bioactive materials, thereby being effectively used as an active component of a composition for delivering bioactive materials.

Coacervate having an ionic polymer mixed with the adhesive protein of a mussel or of a species of the variome thereof

The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novelfoot protein type 5 (MGFP-5) and a recombinant protein that is a hybrid of MGFP-5 and foot protein type 1 (FP-1), where an adhesive protein with adhesive activity can be economically mass-produced to be used in place of chemical adhesives through the present invention.

Growing community of inventors

Pohang-si, South Korea

Hyung Joon Cha