Industry Academic Cooperation Foundation Hallym University

Other

Bio Clue & Solutions Co, Ltd.

Hyung-Joo Kwon

Tae-yoon Kim

Doo-Sik Kim

Won Sik Eum

Jinseu Park

Soo Young Choi

Jin-Hee Choi

Yang-Soon Kim

Dae-Won Kim

The present invention provides an antibody or antigen binding fragment thereof, that binds to TM4SF5, and uses thereof. The antibody of this invention inhibits the growth, metastasis and invasion of cancer cells expressing TM4SF5 by binding to a tumor-specific antigen, TM4SF5, with high affinity, and therefore can be used to diagnose, prevent or treat various cancers expressing TM4SF5.

Antibodies against TM4SF5 and methods of use thereof

The present invention relates to a composition for enhancing an immune response, an epitope having immunogenicity, screening and preparing method thereof, a antibody to peptide antigen and screening and preparing method thereof. The composition of the present invention may be effectively used for preventing or treating diverse immune-deficiency diseases such as cancer, influenza virus, hepatitis C virus and RSV (respiratory syncytial virus) by enhancing immune responses.

Immunostimulatory compositions comprising liposome-encapsulated oligonucleotides and epitopes

Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.

Therapeutic use of CPG oligodeoxynucleotide for skin disease

Disclosed is a fusion protein containing a FK506 binding protein and a cell-transducing domain. Also, disclosed is a method of making the fusion protein and use of the fusion protein in a pharmaceutical or cosmetic composition. The cell-transducing domain is, for example, a PEP-1.

Fusion protein comprising FK506 binding protein and DNA encoding the same

Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.

Growing community of inventors

Cheongju-si, South Korea

Hyung-Joo Kwon