Seoul National University

Autotac Inc.

Kia Motors Corporation

Hyundai Motor Company

Hyundai Autoever Corporation

Hyun Tae Kim

Yong Tae Kwon

Chang Hoon Ji

Ji Eun Lee

Su Jin Kim

Sung Soo Park

Chang Woo Chun

Ki Woon Sung

Su Hyun Park

Jeong Eun Na

Sang Goo Lee

Hee Yeon Kim

Eui Jung Jung

Chan Hoon Jung

Srinivasrao Ganipisetti

Su Ran Mun

Chang Min Park

Min Ju Lee

Kang Min Yoo

Ji Hun Choi

You Hyun Shin

Ah Jung Heo

Eun Hye Jeong

Ha Rim Choi

Chang An Jung

Chan Ill Park

Jung Kuk Lee

Sang Hwan Bae

The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

Compound as a UBR box domain ligand

One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Cargo delivery system and composition comprising the same

The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.

Benzyloxy pyridine derivatives and uses thereof

A syntactic analysis apparatus according to an embodiment of the present disclosure may include an input device receiving a phrase uttered from a user, and a learning device performing at least one or more of extension of an intent output layer for classifying an utterance intent of the user from the uttered phrase and extension of a slot output layer for classifying a slot including information of the phrase and extending a pre-generated utterance syntactic analysis model, such that the uttered phrase is classified into the extended intent output layer and the extended slot output layer, thereby broadly classifying an intent and a slot for the phrase uttered from a user.

Syntactic analysis apparatus and method for the same

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Seoul, South Korea

Hyun Tae Kim