Postech Academy-industry Foundation

Hyun Soo Cho

Sung Ho Ryu

Jun Ho Chung

Kyung Lock Kim

Ji Ho Yoo

Su Min Yoon

Sang Uk Kim

Yoon Sup Choi

The present invention relates to a method for preparing a target-specific non-antibody protein, and more particularly, to a method for preparing a target-specific non-antibody protein comprising the steps of: selecting non-antibody proteins having a structural complementarity with the target site of a target protein in a non-antibody protein library; calculating a binding energy of the selected non-antibody protein and the target protein; selecting a non-antibody protein having a favorable binding energy among the selected non-antibody proteins; selecting amino acid residues having a high binding energy among the interfacial amino acid residues of the selected non-antibody protein and the target protein; and substituting the selected amino acid residues with the amino acid residues having a low binding energy. In addition, the present invention relates to a target-specific non-antibody specifically binding with EGFR (Epidermal Growth Factor Receptor) domain 2, which is prepared by the method, and a cancer therapeutic composition comprising the same.

Target-specific non-antibody protein and method for preparing the same

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Gyeonggi, South Korea

Hyun Soo Cho