Samsung Electronics Co., Ltd.

Hyun-min Koo

Jae-chan Park

Ji-Eun Kim

Jin-Woo Kim

Jin-hwan Park

Woo-Yong Lee

Young-min Lee

Kyu-Sang Lee

Ju-young Lee

Joon-song Park

Hwa-young Cho

Soon-chun Chung

Young-kyoung Park

A recombinantly modifiedmicroorganism with an improved 1,4-butanediol (1,4-BDO) productivity relative to an unmodifiedmicroorganism, wherein activity of an enzyme catalyzing a conversion reaction between malate and oxaloacetate is inactivated or reduced relative to an unmodifiedmicroorganism, as well as a method of making and using same.

Mutant microorganism having improved 1,4-BDO productivity and method of preparing 1,4-BDO using the mutant microorganism

Provided is a method of simultaneous co-integration of multiple nucleic acid sequences into a microbial organism comprising culturing a microbial organism to be transformed until a growth phase is reached in which a random integration is facilitated; and transforming the microbial organism by mixing the cultured microbial organism with a sample to be co-integrated into the microbial organism with, wherein the sample comprises more than one nucleic acid sequence, and the products generated from the method.

Method of construction of recombinant organisms using multiple genes co-integration

Growing community of inventors

Seoul, South Korea

Hyun-min Koo