Korea Research Institute of Bioscience and Biotechnology

Bioleaders Corporation

Hyun-mi Pyo

Moon-Hee Sung

Chul-Joong Kim

Ha Ryoung Poo

Sue-nie Park

Jong-Soo Lee

Chang-Min Jung

Seung Pyo Hong

Seong-Pyo Hong

Jong Soo Lee

Chang Min Jung

Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-&#x3c7;-glutamic acid synthetase complex (pgsBCA) of asp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.

Vector for anti-HPV vaccine and transformed microorganism by the vector

Expression vectors are described that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-&#x3c7;-glutamic acid synthetase complex (pgsBCA) of asp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus, Methodology for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.

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Seo-gu, South Korea

Hyun-mi Pyo