Korea Institute of Radiological & Medical Sciences

Hyun Kyung Choi

Jie Young Song

Ji Yeon Ahn

In Sung Jung

Ky Youb Nam

Saelooom Lee

Seung Yong Seo

Arang Son

Yuan Yue

Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.

Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient

Growing community of inventors

Suwon-si, South Korea

Hyun Kyung Choi