Wyeth

Fidia Advanced Biopolymers S.r.l.

Genetics Institute, Inc.

Etex Corporation

Hyun Kim

Rebecca Li

Howard Seeherman

John Martin Wozney

Lanfranco Callegaro

Alessandra Pavesio

Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.

Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins

Methods of using an injectable or implantable rod-shaped formulation for delivery of osteogenic proteins to treat osteoporotic and/or osteopenic bone are disclosed. The formulation comprises hyaluronic acid derivatives and osteogenic proteins, and optional excipients and active ingredients such as a bone resorption inhibitor.

Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins

An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.

Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins

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Bedford, MA, United States of America

Hyun Kim