Dong-a St Co., Ltd.

Dong-a Pharm. Co., Ltd.

Hyun-Jung Sung

Sung-Hak Choi

Weon-Bin Im

Soon-Hoe Kim

Sun-Ho Choi

Jung-Sang Park

Mi-Yeon Kim

Ji-Hoon Choi

Min-Jung Lee

Jin-Hyuk Kim

Chong-Hwan Cho

Hyung-Keun Lee

Kang-Hun Cho

Jong-Jin Lee

Seung-Bum Ha

Sang-Kuk Park

Won-Bin Leem

Jong-Hwan Cho

Tae-Hoo Lee

Dong-Goo Kim

Jae-Gul Lee

Tae-Kyoung Sohn

Ju-Hee Sohn

Yoon-Jung Kim

Cheon-Hyoung Park

Seung-Hyun Song

Jun-Hwan Moon

Ho-Sang Moon

The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O&#x2014;(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.

Tetrahydropyridine derivatives and their use as antibacterial agents

The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.

Tricyclic benzoxaborole compound, preparation method and use thereof

The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HTreceptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HTreceptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HTreceptors.

Benzamide derivatives

The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

Oxazolidinone derivatives and a process for the preparation thereof

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Gyeonggi-do, South Korea

Hyun-Jung Sung