Dong-a St Co., Ltd.

Km Transderm Ltd.

Hyun-Jung Kim

Masaoki Goto

Sun-Woo Jang

Kwang-Ho Cha

Chang-Yell Shin

Hae-Sun Kim

Jeong-Soo Kim

Sang-Min Hyun

A percutaneous absorption preparation including donepezil for the treatment of dementia is disclosed. The percutaneous absorption preparation for the treatment of dementia includes a support layer, a drug-containing layer, and a release layer, wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; monothioglycerol, thiocyanate metal salt (preferably potassium salt) or dimethylthiourea as a stabilizer; and a pressure-sensitive adhesive. Also disclosed is a percutaneous absorption preparation for the treatment of dementia with reduced the formation of donepezil impurities.

Percutaneous absorption preparation comprising stabilized donepezil

A percutaneous absorption preparation is disclosed. The percutaneous absorption preparation contains donepezil for treatment of dementia, wherein the preparation includes: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer ('SIS') as adhesive. The percutaneous absorption preparation has low skin irritation and high skin penetration.

Percutaneous absorption preparation for treating dementia comprising donepezil

Growing community of inventors

Yongin-Si, South Korea

Hyun-Jung Kim