Celltrion Inc.

Hyun Joo Lee

Shin Jae Chang

Kye Sook Yi

Ki Sung Kwon

Jong Mook Kim

Min Seok Chang

Hwang Keun Jun

Jae Won Jeon

The present invention relates to a binding molecule having influenza A virus-neutralizing activity derived from a human B cell, and the binding molecule having the influenza A virus-neutralizing activity, according to the present invention, is a binding molecule that is derived from a B cell that is selected from the blood of a patient infected with an influenza A virus, and has neutralizing activity against influenza A viruses, and thus is useful in preventing and treating disease derived from the influenza A virus, and can be useful in diagnosing the influenza A virus by using the binding molecule according to the present invention.

Binding molecule having influenza A virus-neutralizing activity produced from human B cell

The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with influenza A viruses, wherein the monoclonal antibodies have neutralizing activity against influenza A viruses. The anti-influenza A virus monoclonal antibody of the present invention has binding and neutralizing activities against at least one influenza A virus selected from the group consisting of influenza A virus H1, H2 and H5 subtypes, and thus it is useful for the prevention and treatment of a disease caused by the influenza A virus and is also useful for diagnosis of influenza A virus infection.

Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses

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Incheon, South Korea

Hyun Joo Lee