Korea Advanced Institute of Science and Technology

Korea Basic Science Institute

Hyun Joo An

Jae-Han Kim

Jong Shin Yoo

Jin Young Kim

Ju Yeon Lee

Jung Hoe Kim

Gun Wook Park

Jin Man Kim

Hyun Kyoung Lee

Sung Hyeon Lee

Seung Yeol Park

Myung Jin Oh

This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.

Diagnostic method for gastric cancer

The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.

Bioinformatics platform for high-throughput identification and quantification of N&#x2014;glycopeptide

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Daejeon, South Korea

Hyun Joo An