Legochem Biosciences, Inc.

Ligachem Biosciences Inc.

Hyun Jin Kwon

Yong Zu Kim

Chul-Woong Chung

Sang Eun Chae

Young Lag Cho

Kyu Man Oh

Dae Hyuck Kang

Jeiwook Chae

Yeong Soo Oh

Jeong Hee Ryu

Dae Yon Lee

Yoon Jeong Choi

Ju Hyun Shin

Eun Mi Jung

Yun Ki Kim

Eun Hye Yang

Eun Hye Ban

Min Soo Kim

Chul Soon Park

Sung Ho Woo

Hyang Sook Lee

Sung Min Kim

Tae Kyo Park

Sung Yoon Baek

Hye Kyung Chang

Joung Yul Yun

Young Jae Yang

Soo Bong Ha

Jeung Hie Choi

Hye Jin Heo

Hye Jin Kang

Kyuman Oh

Jeung Soon Choi

Young Zu Kim

The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same. The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.

Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

Substituted dihydroisoxazole derivatives useful as inhibitors of &#x3b2;-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.

Compositions and methods for inhibiting &#x3b2;-lactamase

Compositions and methods for inhibiting beta-lactamase

The present invention relates to novel cephalosporin derivatives represented by X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Cephalosporin derivatives and pharmaceutical compositions thereof

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R, and Rare as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. Compounds of the present invention are effective ingredients for the broad spectrum of antibiotic resistance, exhibit low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Growing community of inventors

Daejeon, South Korea

Hyun Jin Kwon