Seoul National University

Emory University

Hyun-Jai Cho

Young-Bae Park

Hyo-Soo Kim

Young-Sup Yoon

Jong-Han Park

Jin Hur

Yoo-Wook Kwon

Hyun-Jae Kang

Jae-Seung Paek

The present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.

Therapeutic use of CD31 expressing cells

The present invention relates to a technique of using monocytic blood cells to effectively culture and proliferate blood adult stem cells and progenitor cells that only exist in small quantities to effectively obtain large quantities of stem cells. According to the present invention, the limitation of being able to derive only small quantities of stem cells from blood can be overcome, and the pluripotency of stem cells can easily be obtained.

Method for inducing human blood-born hematospheres through aggregate culture and expanding blood adult stem cells and progenitor cells, and stem cell prepared by the same

As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.

The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.

Growing community of inventors

Seoul, South Korea

Hyun-Jai Cho